TY - JOUR
T1 - Tissue reaction to novel customized calcium silicate cement based dental implants. A pilot study in the dog
AU - Fakhrzadeh, Amir
AU - Saghiri, Mohammad Ali
AU - Morgano, Steven M.
AU - Sullivan, Andrew
N1 - Funding Information:
MAS is a recipient of New Jersey Health Foundation Innovation Award. This publication is dedicated to the memory of Dr. Lajevardi [39], a legendry pediatrician (1953–2015) who passed away. We will never forget Dr. Lajevardi’s kindness and support. We would like to thank our North American Science Associates (NAMSA) study director, Laura Tasse, and veterinarian, Dr. Kate Hissam for their efforts, without whom this study would not have been possible. Rutgers University’s TechAdvance program supported the research reported in this publication. Additional thanks must be given to Rutgers University’s Office of Research and Economic Development for providing this TechAdvance program, which is an internal funding mechanism designed to support promising Rutgers technologies. Special Thanks to Chun Kai Tang and Dr. Ali Mohammad Saghiri.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/6
Y1 - 2021/6
N2 - Objectives: The purpose of this study was to determine the level of periodontal tissue regeneration in a canine model following post-extraction placement of an implant molded from a composite material made from extracted tooth dentin and a calcium silicate cement (CSC) material. The investigation used autologous dentin in conjunction with a CSC material to form a composite implant designed for immediate tooth replacement. Methods: Two (2) beagles had a periodontal and radiographic examination performed to rule out any pre-treatment inflammation, significant periodontal disease, or mobility. Then, ination eleven (11) teeth were extracted and polyvinyl siloxane molds were made to fabricate three different types of implants: Particulate Implant (Test Group 1, n = 4), Shell Implant Alone (Test Group 2, n = 2), Shell Implant with Emdogain® (Test Group 3, n = 3). Teeth in the control group were extracted, scaled (n = 2), and then re-implanted into their respective fresh extraction sockets. At 4 weeks, a clinical, radiographic, and histologic assessment was performed. Results: Clinical evaluation revealed no mobility in any of the test or control implants and no radiographic evidence of significant bone loss or active disease. Based on the MicroCT analysis, direct bone to implant contact was observed in some areas with an apparent periodontal ligament space. Implant-related inflammation, on average, was similar among all groups, with low numbers of infiltrates. Implant-related inflammatory reaction was generally minimal and not interpreted to be adverse. Conclusion: The proposed novel composite materials revealed that not only do these materials demonstrate high biocompatibility, but also their successful integration in the alveolus is likely secondary to a partial ligamentous attachment. The current investigation may lead to the use of calcium silicate-based materials as custom dental implants. Further research on this novel composite’s biomechanical properties is necessary to develop the optimal material composition for use as a load-bearing dental implant. [Figure not available: see fulltext.]
AB - Objectives: The purpose of this study was to determine the level of periodontal tissue regeneration in a canine model following post-extraction placement of an implant molded from a composite material made from extracted tooth dentin and a calcium silicate cement (CSC) material. The investigation used autologous dentin in conjunction with a CSC material to form a composite implant designed for immediate tooth replacement. Methods: Two (2) beagles had a periodontal and radiographic examination performed to rule out any pre-treatment inflammation, significant periodontal disease, or mobility. Then, ination eleven (11) teeth were extracted and polyvinyl siloxane molds were made to fabricate three different types of implants: Particulate Implant (Test Group 1, n = 4), Shell Implant Alone (Test Group 2, n = 2), Shell Implant with Emdogain® (Test Group 3, n = 3). Teeth in the control group were extracted, scaled (n = 2), and then re-implanted into their respective fresh extraction sockets. At 4 weeks, a clinical, radiographic, and histologic assessment was performed. Results: Clinical evaluation revealed no mobility in any of the test or control implants and no radiographic evidence of significant bone loss or active disease. Based on the MicroCT analysis, direct bone to implant contact was observed in some areas with an apparent periodontal ligament space. Implant-related inflammation, on average, was similar among all groups, with low numbers of infiltrates. Implant-related inflammatory reaction was generally minimal and not interpreted to be adverse. Conclusion: The proposed novel composite materials revealed that not only do these materials demonstrate high biocompatibility, but also their successful integration in the alveolus is likely secondary to a partial ligamentous attachment. The current investigation may lead to the use of calcium silicate-based materials as custom dental implants. Further research on this novel composite’s biomechanical properties is necessary to develop the optimal material composition for use as a load-bearing dental implant. [Figure not available: see fulltext.]
UR - http://www.scopus.com/inward/record.url?scp=85106736910&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85106736910&partnerID=8YFLogxK
U2 - 10.1007/s10856-021-06512-y
DO - 10.1007/s10856-021-06512-y
M3 - Article
C2 - 34021848
AN - SCOPUS:85106736910
SN - 0957-4522
VL - 32
JO - Journal of Materials Science: Materials in Electronics
JF - Journal of Materials Science: Materials in Electronics
IS - 6
M1 - 61
ER -