Tissue-Specific and Developmentally Regulated Transcription of the Insulin-Like Growth Factor 2 Gene

Alane Gray; Albert W. Tam; Thomas J. Dull; Joel Hayflick; John Pintar; Webster K. Cavenee; Alex Koufos; Axel Ullrich

doi:10.1089/dna.1987.6.283

Tissue-Specific and Developmentally Regulated Transcription of the Insulin-Like Growth Factor 2 Gene

Alane Gray, Albert W. Tam, Thomas J. Dull, Joel Hayflick, John Pintar, Webster K. Cavenee, Alex Koufos, Axel Ullrich

Research output: Contribution to journal › Article › peer-review

135 Scopus citations

Abstract

Transcription of the rat and human IGF-2 gene loci is unusually complex. The pattern of expression of these genes varies both between tissues and within a given tissue during different stages of development. Alternative splicing or possibly transcriptional initiation events generate variant IGF-2 mRNAs that contain different 5′-untranslated leader sequences. These leader exon sequences are shared with non-IGF-2 mRNAs. Certain noncoding IGF-2 gene sequence elements are transcribed extensively and are found in multiple copies elsewhere in the human genome. Furthermore, IGF-2 mRNA levels are particularly high in a variety of human malignancies.

Original language	English (US)
Pages (from-to)	283-295
Number of pages	13
Journal	DNA
Volume	6
Issue number	4
DOIs	https://doi.org/10.1089/dna.1987.6.283
State	Published - Aug 1987
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Genetics

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10.1089/dna.1987.6.283

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title = "Tissue-Specific and Developmentally Regulated Transcription of the Insulin-Like Growth Factor 2 Gene",

abstract = "Transcription of the rat and human IGF-2 gene loci is unusually complex. The pattern of expression of these genes varies both between tissues and within a given tissue during different stages of development. Alternative splicing or possibly transcriptional initiation events generate variant IGF-2 mRNAs that contain different 5′-untranslated leader sequences. These leader exon sequences are shared with non-IGF-2 mRNAs. Certain noncoding IGF-2 gene sequence elements are transcribed extensively and are found in multiple copies elsewhere in the human genome. Furthermore, IGF-2 mRNA levels are particularly high in a variety of human malignancies.",

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AU - Gray, Alane

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AU - Dull, Thomas J.

AU - Hayflick, Joel

AU - Pintar, John

AU - Cavenee, Webster K.

AU - Koufos, Alex

AU - Ullrich, Axel

PY - 1987/8

Y1 - 1987/8

N2 - Transcription of the rat and human IGF-2 gene loci is unusually complex. The pattern of expression of these genes varies both between tissues and within a given tissue during different stages of development. Alternative splicing or possibly transcriptional initiation events generate variant IGF-2 mRNAs that contain different 5′-untranslated leader sequences. These leader exon sequences are shared with non-IGF-2 mRNAs. Certain noncoding IGF-2 gene sequence elements are transcribed extensively and are found in multiple copies elsewhere in the human genome. Furthermore, IGF-2 mRNA levels are particularly high in a variety of human malignancies.

AB - Transcription of the rat and human IGF-2 gene loci is unusually complex. The pattern of expression of these genes varies both between tissues and within a given tissue during different stages of development. Alternative splicing or possibly transcriptional initiation events generate variant IGF-2 mRNAs that contain different 5′-untranslated leader sequences. These leader exon sequences are shared with non-IGF-2 mRNAs. Certain noncoding IGF-2 gene sequence elements are transcribed extensively and are found in multiple copies elsewhere in the human genome. Furthermore, IGF-2 mRNA levels are particularly high in a variety of human malignancies.

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Tissue-Specific and Developmentally Regulated Transcription of the Insulin-Like Growth Factor 2 Gene

Abstract

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