Tissue welding with virus-sterilized human cryoprecipitate

Mathew R. Williams, Christian I. Fras, Richard Moscarelli, Steven K. Libutti, Mehmet C. Oz, Lawrence S. Bass, Adrianne J. Setton, Murat Kaynar, Roman Nowygrod, Michael R. Treat

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations

Abstract

Clinical use of laser tissue soldering with cryoprecipitate has been delayed by the fear of infecting recipients with donor viral products. Solvent-Detergent (S/D) treatment of human plasma is a technique for disrupting membrane enveloped viruses and rendering them noninfectious. Dual 6 cm incisions were created on the dorsum of nine rats and closed with either standard skin staples or with laser activated S/D cryoprecipitate. The animals were sacrificed at one of three time periods: 0, 2, and 4 days. The use of the laser tissue solder significantly improved tensile strength over standard skin closures at all time periods. Tensile strengths (kg force/sq. cm) for the laser group were: 0.22 + 0.08 (0 day), 0.77 + 0.37 (2 day), and 0.84 + 0.30 (4 day). Comparable results for the control group were significantly different (p <0.05): 0.00 (0 day), 0.12 + 0.03 ( 2 day), and 0.36 + 0.21 (4 day). Deactivation of viral particles during preparation of cryoprecipitate does not reduce the utility of this material as a solder during laser bonding. Reduced infectivity of S/D prepared products enhances their clinical utility.

Original languageEnglish (US)
Pages (from-to)267-270
Number of pages4
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume1643
DOIs
StatePublished - Jun 1 1992
Externally publishedYes
EventLaser Surgery: Advanced Characterization, Therapeutics, and Systems III 1992 - Los Angeles, United States
Duration: Jan 19 1992Jan 24 1992

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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