Abstract
Clinical use of laser tissue soldering with cryoprecipitate has been delayed by the fear of infecting recipients with donor viral products. Solvent-Detergent (S/D) treatment of human plasma is a technique for disrupting membrane enveloped viruses and rendering them noninfectious. Dual 6 cm incisions were created on the dorsum of nine rats and closed with either standard skin staples or with laser activated S/D cryoprecipitate. The animals were sacrificed at one of three time periods: 0, 2, and 4 days. The use of the laser tissue solder significantly improved tensile strength over standard skin closures at all time periods. Tensile strengths (kg force/sq. cm) for the laser group were: 0.22 + 0.08 (0 day), 0.77 + 0.37 (2 day), and 0.84 + 0.30 (4 day). Comparable results for the control group were significantly different (p <0.05): 0.00 (0 day), 0.12 + 0.03 ( 2 day), and 0.36 + 0.21 (4 day). Deactivation of viral particles during preparation of cryoprecipitate does not reduce the utility of this material as a solder during laser bonding. Reduced infectivity of S/D prepared products enhances their clinical utility.
Original language | English (US) |
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Pages (from-to) | 267-270 |
Number of pages | 4 |
Journal | Proceedings of SPIE - The International Society for Optical Engineering |
Volume | 1643 |
DOIs | |
State | Published - Jun 1 1992 |
Externally published | Yes |
Event | Laser Surgery: Advanced Characterization, Therapeutics, and Systems III 1992 - Los Angeles, United States Duration: Jan 19 1992 → Jan 24 1992 |
All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Computer Science Applications
- Applied Mathematics
- Electrical and Electronic Engineering