Tocopherols in cancer

An update

Soumyasri Das Gupta, Nanjoo Suh

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Tocopherols exist in four forms designated as α, β, δ, and γ. Due to their strong antioxidant properties, tocopherols have been suggested to reduce the risk of cancer. Cancer prevention studies with tocopherols have mostly utilized α-tocopherol. Large-scale clinical trials with α-tocopherol provided inconsistent results regarding the cancer-preventive activities of tocopherols. This review summarizes our current understanding of the anticancer activities of different forms of tocopherols based on follow-up of the clinical trials, recent epidemiological evidences, and experimental studies using in vitro and in vivo models. The experimental data provide strong evidence in support of the anticancer activities of δ-tocopherol, γ-tocopherol, and the natural tocopherol mixture rich in γ-tocopherol, γ-TmT, over α-tocopherol. Such outcomes emphasize the need for detailed investigation into the cancer-preventive activities of different forms of tocopherols to provide a strong rationale for intervention studies in the future.

Original languageEnglish (US)
Pages (from-to)1354-1363
Number of pages10
JournalMolecular nutrition & food research
Volume60
Issue number6
DOIs
StatePublished - Jun 1 2016

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Tocopherols
tocopherols
neoplasms
Neoplasms
clinical trials
Clinical Trials
in vitro studies

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science

Keywords

  • Cancer prevention
  • Tocopherols
  • Vitamin E

Cite this

Das Gupta, Soumyasri ; Suh, Nanjoo. / Tocopherols in cancer : An update. In: Molecular nutrition & food research. 2016 ; Vol. 60, No. 6. pp. 1354-1363.
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Tocopherols in cancer : An update. / Das Gupta, Soumyasri; Suh, Nanjoo.

In: Molecular nutrition & food research, Vol. 60, No. 6, 01.06.2016, p. 1354-1363.

Research output: Contribution to journalReview article

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T1 - Tocopherols in cancer

T2 - An update

AU - Das Gupta, Soumyasri

AU - Suh, Nanjoo

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N2 - Tocopherols exist in four forms designated as α, β, δ, and γ. Due to their strong antioxidant properties, tocopherols have been suggested to reduce the risk of cancer. Cancer prevention studies with tocopherols have mostly utilized α-tocopherol. Large-scale clinical trials with α-tocopherol provided inconsistent results regarding the cancer-preventive activities of tocopherols. This review summarizes our current understanding of the anticancer activities of different forms of tocopherols based on follow-up of the clinical trials, recent epidemiological evidences, and experimental studies using in vitro and in vivo models. The experimental data provide strong evidence in support of the anticancer activities of δ-tocopherol, γ-tocopherol, and the natural tocopherol mixture rich in γ-tocopherol, γ-TmT, over α-tocopherol. Such outcomes emphasize the need for detailed investigation into the cancer-preventive activities of different forms of tocopherols to provide a strong rationale for intervention studies in the future.

AB - Tocopherols exist in four forms designated as α, β, δ, and γ. Due to their strong antioxidant properties, tocopherols have been suggested to reduce the risk of cancer. Cancer prevention studies with tocopherols have mostly utilized α-tocopherol. Large-scale clinical trials with α-tocopherol provided inconsistent results regarding the cancer-preventive activities of tocopherols. This review summarizes our current understanding of the anticancer activities of different forms of tocopherols based on follow-up of the clinical trials, recent epidemiological evidences, and experimental studies using in vitro and in vivo models. The experimental data provide strong evidence in support of the anticancer activities of δ-tocopherol, γ-tocopherol, and the natural tocopherol mixture rich in γ-tocopherol, γ-TmT, over α-tocopherol. Such outcomes emphasize the need for detailed investigation into the cancer-preventive activities of different forms of tocopherols to provide a strong rationale for intervention studies in the future.

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