Tonic firing of rat nucleus accumbens neurons: Changes during the first 2 weeks of daily cocaine self-administration sessions

Laura L. Peoples, Anthony J. Uzwiak, Fred Gee, Mark O. West

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Activity of single neurons in the nucleus accumbens (NAcc) of rats was recorded extracellularly on the 2nd and 15th days of intravenous cocaine self-administration. Each of the two electrophysiological recording sessions consisted of three successive phases: a pre-drug baseline recording period, a cocaine self-administration session, and a post-drug recording period. Firing of individual neurons was typically inhibited during the self-administration session, relative to the pre-drug period. The inhibition was greater on the 15th day relative to the 2nd day. Additionally, firing rates during the pre- drug period and the self-administration session were typically lower on the 15th day as compared to the 2nd day. The present data are consistent with previous acute electrophysiological findings and are in line with the hypothesis that repeated drug self-administration engenders changes in the mesoaccumbens pathway that contribute to drug addiction.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalBrain research
Volume822
Issue number1-2
DOIs
StatePublished - Mar 20 1999

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • Addiction
  • Cocaine
  • Electrophysiology
  • Nucleus accumbens
  • Rat
  • Self- administration

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