The grey lethal mouse is an osteopetrotic mutant in which there is failure of physiologic bone resorption. Thirty grey lethals received daily subcutaneous injections of saline, beginning within 24 hr of birth. No molar teeth erupted in any of the 20 of these controls which survived until 20 days of age, the stage at which there is appreciable molar eruption in normal mice of this strain. Daily subcutaneous injections of parathyroid extract, beginning within 24 hr of birth, significantly increased the incidence of molar teeth eruption.
All Science Journal Classification (ASJC) codes
- Cell Biology