Topographic changes in a heterochromatic chromosome block in humans (15P) during formation of the nucleolus

Frederick S. Kaplan, J. Patrick O'Connor

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Fluorescence in situ hybridization and multispectral confocal laser scanning microscopy revealed a highly dynamic nucleolar-associated chromosome 15 satellite III heterochromatin cluster in humans. This nucleolar-associated DNA was highly decondensed at the metaphase plate compared with its topography at interphase and appeared to act as a centre for the postmitotic reorganization of the nucleolus. Our data showed unexpected trans-mitotic changes in the topography of this nucleolar-associated satellite III DNA that suggest that this locus-specific heterochromatin superstructure may be involved in nucleolar organization.

Original languageEnglish (US)
Pages (from-to)309-314
Number of pages6
JournalChromosome Research
Volume3
Issue number5
DOIs
StatePublished - Aug 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics

Keywords

  • chromosomes
  • decondensed heterochromatin
  • mitosis
  • nucleolus
  • satellite DNA

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