Topography of murine leukemia virus envelope proteins: Characterization of transmembrane components

A. Pinter, W. J. Honnen

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Trypsinization of intact Moloney murine leukemia virus resulted in cleavage of p15(E) and Pr15(E) at a site near the middle of the molecule, producing a 9,000-dalton amino-terminal fragment which contains the disulfide linkage site to gp70 and which carries p15(E) epitopes b and c, but not epitope a. After solubilization of the viral membrane, trypsinization occurred at a second site within 1,000 daltons of the carboxy end of p15(E). This site is not exposed in intact virions, indicating that p15(E) and Pr15(E) are transmembrane proteins.

Original languageEnglish (US)
Pages (from-to)1056-1060
Number of pages5
JournalJournal of virology
Volume46
Issue number3
DOIs
StatePublished - 1983
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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