Abstract
Trypsinization of intact Moloney murine leukemia virus resulted in cleavage of p15(E) and Pr15(E) at a site near the middle of the molecule, producing a 9,000-dalton amino-terminal fragment which contains the disulfide linkage site to gp70 and which carries p15(E) epitopes b and c, but not epitope a. After solubilization of the viral membrane, trypsinization occurred at a second site within 1,000 daltons of the carboxy end of p15(E). This site is not exposed in intact virions, indicating that p15(E) and Pr15(E) are transmembrane proteins.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1056-1060 |
| Number of pages | 5 |
| Journal | Journal of virology |
| Volume | 46 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1983 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Microbiology
- Immunology
- Insect Science
- Virology