Toward a genome-wide landscape of translational control

Ola Larsson, Bin Tian, Nahum Sonenberg

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Genome-wide analysis of translational control has taken strides in recent years owing to the advent of high-throughput technologies, including DNA microarrays and deep sequencing. Global studies have unraveled a principal role, among posttranscriptional mechanisms, for mRNAtranslation in determining protein levels in the cell. The impact of translational control in dynamic regulation of the proteome under different conditions is increasingly appreciated. Here we review genome-wide studies that use high-throughput techniques and bioinformatics to assess the role of mRNA translation in the regulation of protein levels; we also discuss howgenome-wide data onmRNA translation can be obtained, analyzed, and used to identify mechanisms of translational control.

Original languageEnglish (US)
JournalCold Spring Harbor Perspectives in Biology
Volume5
Issue number1
DOIs
StatePublished - Jan 2013

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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