@inproceedings{ca0e839d2a8d4dd4802f5ac224b30a39,
title = "Toward in vivo targeting delivery of siRNA for efficient cancer therapy",
abstract = "The main obstacle in siRNA therapy is RNA delivery to the cytoplasm, where it can guide sequence-specific mRNA degradation. Attempts to develop effective nonviral vectors for in vivo delivery of nucleic acids through a systemic route are hampered by difficulties of combining high extracellular stability with ready availability of the nucleic acids following entry into cells. Other challenges with non-viral gene delivery include limitations in target-cell specificity. Here we report a targeted siRNA delivery vector that displays good extracellular stability and intracellular bioavailability to permit efficient gene silencing.",
keywords = "Dendrimers, PPI, Poly(propyleneimine), Targeted delivery, siRNA",
author = "O. Taratula and P. Kirkpatrick and R. Savla and I. Pandya and T. Minko and H. He",
year = "2008",
language = "English (US)",
isbn = "9781420085075",
series = "Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008",
pages = "346--349",
booktitle = "Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008",
note = "2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008 ; Conference date: 01-06-2008 Through 05-06-2008",
}