Toxicity of Nonsteroidal Anti-Inflammatory Drugs: An Overview of the Epidemiological Evidence

Jeffrey Carson, L. Rees Willett

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used throughout the world. This paper reviews the epidemiological data linking NSAID administration with gastrointestinal, hepatic, renal, haematological, and hypersensitivity reactions. Meta-analysis has demonstrated that NSAIDs are associated with serious upper gastrointestinal disorders, with a relative risk of 2.7 in patients receiving NSAIDs compared with subjects not receiving NSAIDs. An increase in the dose and duration of NSAIDs and age >60 are associated with an increase in the risk of upper gastrointestinal toxicity. The current data strongly support a causal relationship between NSAIDs and gastrointestinal disorders. Case-control studies have demonstrated an association between some NSAIDs and neutropenia, with a relative risk of between 3 and 9 in patients treated with NSAIDs compared with nonusers of these drugs. NSAIDs have also been linked with hypersensitivity reactions, although the incidence of such reactions is very low. However, there are inconsistent data on the potential associations between NSAIDs and renal disease, and there are no epidemiological studies linking NSAIDs with acute liver disease. Overall, the incidence of serious adverse reactions associated with NSAIDs is low, and this class of drugs can be regarded as being reasonably safe.

Original languageEnglish (US)
Pages (from-to)243-248
Number of pages6
JournalDrugs
Volume46
Issue number1
DOIs
StatePublished - Jan 1 1993

Fingerprint

Anti-Inflammatory Agents
Pharmaceutical Preparations
Hypersensitivity
Gastrointestinal Agents
Kidney
Incidence
Acute Disease
Neutropenia
Meta-Analysis
Case-Control Studies
Liver Diseases
Epidemiologic Studies
Liver

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

Cite this

@article{2be55e70695a4f79be8d596ff74f3f46,
title = "Toxicity of Nonsteroidal Anti-Inflammatory Drugs: An Overview of the Epidemiological Evidence",
abstract = "Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used throughout the world. This paper reviews the epidemiological data linking NSAID administration with gastrointestinal, hepatic, renal, haematological, and hypersensitivity reactions. Meta-analysis has demonstrated that NSAIDs are associated with serious upper gastrointestinal disorders, with a relative risk of 2.7 in patients receiving NSAIDs compared with subjects not receiving NSAIDs. An increase in the dose and duration of NSAIDs and age >60 are associated with an increase in the risk of upper gastrointestinal toxicity. The current data strongly support a causal relationship between NSAIDs and gastrointestinal disorders. Case-control studies have demonstrated an association between some NSAIDs and neutropenia, with a relative risk of between 3 and 9 in patients treated with NSAIDs compared with nonusers of these drugs. NSAIDs have also been linked with hypersensitivity reactions, although the incidence of such reactions is very low. However, there are inconsistent data on the potential associations between NSAIDs and renal disease, and there are no epidemiological studies linking NSAIDs with acute liver disease. Overall, the incidence of serious adverse reactions associated with NSAIDs is low, and this class of drugs can be regarded as being reasonably safe.",
author = "Jeffrey Carson and {Rees Willett}, L.",
year = "1993",
month = "1",
day = "1",
doi = "10.2165/00003495-199300461-00063",
language = "English (US)",
volume = "46",
pages = "243--248",
journal = "Drugs",
issn = "0012-6667",
publisher = "Adis International Ltd",
number = "1",

}

Toxicity of Nonsteroidal Anti-Inflammatory Drugs : An Overview of the Epidemiological Evidence. / Carson, Jeffrey; Rees Willett, L.

In: Drugs, Vol. 46, No. 1, 01.01.1993, p. 243-248.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Toxicity of Nonsteroidal Anti-Inflammatory Drugs

T2 - An Overview of the Epidemiological Evidence

AU - Carson, Jeffrey

AU - Rees Willett, L.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used throughout the world. This paper reviews the epidemiological data linking NSAID administration with gastrointestinal, hepatic, renal, haematological, and hypersensitivity reactions. Meta-analysis has demonstrated that NSAIDs are associated with serious upper gastrointestinal disorders, with a relative risk of 2.7 in patients receiving NSAIDs compared with subjects not receiving NSAIDs. An increase in the dose and duration of NSAIDs and age >60 are associated with an increase in the risk of upper gastrointestinal toxicity. The current data strongly support a causal relationship between NSAIDs and gastrointestinal disorders. Case-control studies have demonstrated an association between some NSAIDs and neutropenia, with a relative risk of between 3 and 9 in patients treated with NSAIDs compared with nonusers of these drugs. NSAIDs have also been linked with hypersensitivity reactions, although the incidence of such reactions is very low. However, there are inconsistent data on the potential associations between NSAIDs and renal disease, and there are no epidemiological studies linking NSAIDs with acute liver disease. Overall, the incidence of serious adverse reactions associated with NSAIDs is low, and this class of drugs can be regarded as being reasonably safe.

AB - Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used throughout the world. This paper reviews the epidemiological data linking NSAID administration with gastrointestinal, hepatic, renal, haematological, and hypersensitivity reactions. Meta-analysis has demonstrated that NSAIDs are associated with serious upper gastrointestinal disorders, with a relative risk of 2.7 in patients receiving NSAIDs compared with subjects not receiving NSAIDs. An increase in the dose and duration of NSAIDs and age >60 are associated with an increase in the risk of upper gastrointestinal toxicity. The current data strongly support a causal relationship between NSAIDs and gastrointestinal disorders. Case-control studies have demonstrated an association between some NSAIDs and neutropenia, with a relative risk of between 3 and 9 in patients treated with NSAIDs compared with nonusers of these drugs. NSAIDs have also been linked with hypersensitivity reactions, although the incidence of such reactions is very low. However, there are inconsistent data on the potential associations between NSAIDs and renal disease, and there are no epidemiological studies linking NSAIDs with acute liver disease. Overall, the incidence of serious adverse reactions associated with NSAIDs is low, and this class of drugs can be regarded as being reasonably safe.

UR - http://www.scopus.com/inward/record.url?scp=0027443348&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027443348&partnerID=8YFLogxK

U2 - 10.2165/00003495-199300461-00063

DO - 10.2165/00003495-199300461-00063

M3 - Article

C2 - 7506183

AN - SCOPUS:0027443348

VL - 46

SP - 243

EP - 248

JO - Drugs

JF - Drugs

SN - 0012-6667

IS - 1

ER -