Toxicological evaluation of a chicory root extract

Barbara M. Schmidt; Nebojsa Ilic; Alexander Poulev; Ilya Raskin

doi:10.1016/j.fct.2006.12.019

Toxicological evaluation of a chicory root extract

Barbara M. Schmidt, Nebojsa Ilic, Alexander Poulev, Ilya Raskin

School of Environmental and Biological Sciences, Plant Biology

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

An Ames test and a 28-day sub-chronic toxicity study in male and female Sprague-Dawley rats were conducted to evaluate the safety of a chicory root extract being investigated as a therapeutic for inflammation. Chicory extract had no mutagenic activity in the Ames test although it was cytotoxic to certain strains of Salmonella at higher doses with and without metabolic activation. For the 28-day rat study, measurements included clinical observations, body weights, food consumption, clinical pathology, gross necropsy and histology. There were no treatment-related toxic effects from chicory extract administered orally at 70, 350, or 1000 mg/kg/day. Since there were no observed adverse effects of chicory extract in these studies, the NOAEL for the extract is 1000 mg/kg/g administered orally for 28 days.

Original language	English (US)
Pages (from-to)	1131-1139
Number of pages	9
Journal	Food and Chemical Toxicology
Volume	45
Issue number	7
DOIs	https://doi.org/10.1016/j.fct.2006.12.019
State	Published - Jul 2007

All Science Journal Classification (ASJC) codes

Food Science
Toxicology

Keywords

Ames
Chicorium intybus
Dietary supplement
Inflammation
Sesquiterpene lactone
Toxicity

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10.1016/j.fct.2006.12.019

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title = "Toxicological evaluation of a chicory root extract",

abstract = "An Ames test and a 28-day sub-chronic toxicity study in male and female Sprague-Dawley rats were conducted to evaluate the safety of a chicory root extract being investigated as a therapeutic for inflammation. Chicory extract had no mutagenic activity in the Ames test although it was cytotoxic to certain strains of Salmonella at higher doses with and without metabolic activation. For the 28-day rat study, measurements included clinical observations, body weights, food consumption, clinical pathology, gross necropsy and histology. There were no treatment-related toxic effects from chicory extract administered orally at 70, 350, or 1000 mg/kg/day. Since there were no observed adverse effects of chicory extract in these studies, the NOAEL for the extract is 1000 mg/kg/g administered orally for 28 days.",

keywords = "Ames, Chicorium intybus, Dietary supplement, Inflammation, Sesquiterpene lactone, Toxicity",

author = "Schmidt, {Barbara M.} and Nebojsa Ilic and Alexander Poulev and Ilya Raskin",

note = "Funding Information: Partially supported by Phytomedics Inc., Fogarty International Center of the NIH under U01 TW006674 for the International Cooperative Biodiversity Groups, and Rutgers University and NJ Agricultural Experiment Station.",

year = "2007",

month = jul,

doi = "10.1016/j.fct.2006.12.019",

language = "English (US)",

volume = "45",

pages = "1131--1139",

journal = "Food and Chemical Toxicology",

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T1 - Toxicological evaluation of a chicory root extract

AU - Schmidt, Barbara M.

AU - Ilic, Nebojsa

AU - Poulev, Alexander

AU - Raskin, Ilya

N1 - Funding Information: Partially supported by Phytomedics Inc., Fogarty International Center of the NIH under U01 TW006674 for the International Cooperative Biodiversity Groups, and Rutgers University and NJ Agricultural Experiment Station.

PY - 2007/7

Y1 - 2007/7

N2 - An Ames test and a 28-day sub-chronic toxicity study in male and female Sprague-Dawley rats were conducted to evaluate the safety of a chicory root extract being investigated as a therapeutic for inflammation. Chicory extract had no mutagenic activity in the Ames test although it was cytotoxic to certain strains of Salmonella at higher doses with and without metabolic activation. For the 28-day rat study, measurements included clinical observations, body weights, food consumption, clinical pathology, gross necropsy and histology. There were no treatment-related toxic effects from chicory extract administered orally at 70, 350, or 1000 mg/kg/day. Since there were no observed adverse effects of chicory extract in these studies, the NOAEL for the extract is 1000 mg/kg/g administered orally for 28 days.

AB - An Ames test and a 28-day sub-chronic toxicity study in male and female Sprague-Dawley rats were conducted to evaluate the safety of a chicory root extract being investigated as a therapeutic for inflammation. Chicory extract had no mutagenic activity in the Ames test although it was cytotoxic to certain strains of Salmonella at higher doses with and without metabolic activation. For the 28-day rat study, measurements included clinical observations, body weights, food consumption, clinical pathology, gross necropsy and histology. There were no treatment-related toxic effects from chicory extract administered orally at 70, 350, or 1000 mg/kg/day. Since there were no observed adverse effects of chicory extract in these studies, the NOAEL for the extract is 1000 mg/kg/g administered orally for 28 days.

KW - Ames

KW - Chicorium intybus

KW - Dietary supplement

KW - Inflammation

KW - Sesquiterpene lactone

KW - Toxicity

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U2 - 10.1016/j.fct.2006.12.019

DO - 10.1016/j.fct.2006.12.019

M3 - Article

C2 - 17306431

AN - SCOPUS:34247112746

SN - 0278-6915

VL - 45

SP - 1131

EP - 1139

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

IS - 7

ER -

Toxicological evaluation of a chicory root extract

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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