Toxicological evaluation of a chicory root extract

Barbara M. Schmidt, Nebojsa Ilic, Alexander Poulev, Ilya Raskin

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

An Ames test and a 28-day sub-chronic toxicity study in male and female Sprague-Dawley rats were conducted to evaluate the safety of a chicory root extract being investigated as a therapeutic for inflammation. Chicory extract had no mutagenic activity in the Ames test although it was cytotoxic to certain strains of Salmonella at higher doses with and without metabolic activation. For the 28-day rat study, measurements included clinical observations, body weights, food consumption, clinical pathology, gross necropsy and histology. There were no treatment-related toxic effects from chicory extract administered orally at 70, 350, or 1000 mg/kg/day. Since there were no observed adverse effects of chicory extract in these studies, the NOAEL for the extract is 1000 mg/kg/g administered orally for 28 days.

Original languageEnglish (US)
Pages (from-to)1131-1139
Number of pages9
JournalFood and Chemical Toxicology
Volume45
Issue number7
DOIs
StatePublished - Jul 2007

All Science Journal Classification (ASJC) codes

  • Food Science
  • Toxicology

Keywords

  • Ames
  • Chicorium intybus
  • Dietary supplement
  • Inflammation
  • Sesquiterpene lactone
  • Toxicity

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