Transcription of the multidrug resistance gene MDR1: a therapeutic target.

K. W. Scotto, R. A. Johnson

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations

Abstract

Two decades ago, the overexpression of P-glycoprotein (Pgp) was first demonstrated to mediate the energy-dependent efflux of a variety of chemotherapeutic agents from tumor cells, resulting in the development of multidrug resistance (MDR). Not surprisingly, this discovery triggered an ongoing search for agents that would inhibit Pgp function, with the hope that by doing so the MDR phenotype could be reversed. As our understanding of Pgp function and pharmacokinetics has increased, this quest has become more urgent, as well as more complex.

Original languageEnglish (US)
Pages (from-to)117-125
Number of pages9
JournalMolecular interventions
Volume1
Issue number2
StatePublished - Jun 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine

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