Transcription regulation by bacteriophage T4 AsiA

Leonid Minakhin; Konstantin Severinov

doi:10.1016/j.pep.2004.09.019

Transcription regulation by bacteriophage T4 AsiA

Leonid Minakhin, Konstantin Severinov

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Bacteriophage T4 AsiA, a strong inhibitor of bacterial RNA polymerase, was the first antisigma protein to be discovered. Recent advances that made it possible to purify large amounts of this highly toxic protein led to an increased understanding of AsiA function and structure. In this review, we discuss how the small 10-KDa AsiA protein plays a key role in T4 development through its ability to both inhibit and activate bacterial RNA polymerase transcription.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	Protein Expression and Purification
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/j.pep.2004.09.019
State	Published - May 2005

All Science Journal Classification (ASJC) codes

Biotechnology

Keywords

Antisigma
Bacteriophase T4
RNA polymerase
Transcription regulation

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10.1016/j.pep.2004.09.019

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title = "Transcription regulation by bacteriophage T4 AsiA",

abstract = "Bacteriophage T4 AsiA, a strong inhibitor of bacterial RNA polymerase, was the first antisigma protein to be discovered. Recent advances that made it possible to purify large amounts of this highly toxic protein led to an increased understanding of AsiA function and structure. In this review, we discuss how the small 10-KDa AsiA protein plays a key role in T4 development through its ability to both inhibit and activate bacterial RNA polymerase transcription.",

keywords = "Antisigma, Bacteriophase T4, RNA polymerase, Transcription regulation",

author = "Leonid Minakhin and Konstantin Severinov",

note = "Funding Information: We are grateful to Mark Chlenov, Dr. Seth A. Darst, Dr. E. Peter Geiduschek, and Dr. Sergei Nechaev for allowing to cite their unpublished results. We thank Drs. Deborah Hinton, Ann Hochschild, Sergei Nechaev, and Jeff Urbauer for critical reading of the manuscript. This work was supported by NIH RO1 Grant 59295 to K.S.",

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doi = "10.1016/j.pep.2004.09.019",

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T1 - Transcription regulation by bacteriophage T4 AsiA

AU - Minakhin, Leonid

AU - Severinov, Konstantin

N1 - Funding Information: We are grateful to Mark Chlenov, Dr. Seth A. Darst, Dr. E. Peter Geiduschek, and Dr. Sergei Nechaev for allowing to cite their unpublished results. We thank Drs. Deborah Hinton, Ann Hochschild, Sergei Nechaev, and Jeff Urbauer for critical reading of the manuscript. This work was supported by NIH RO1 Grant 59295 to K.S.

PY - 2005/5

Y1 - 2005/5

N2 - Bacteriophage T4 AsiA, a strong inhibitor of bacterial RNA polymerase, was the first antisigma protein to be discovered. Recent advances that made it possible to purify large amounts of this highly toxic protein led to an increased understanding of AsiA function and structure. In this review, we discuss how the small 10-KDa AsiA protein plays a key role in T4 development through its ability to both inhibit and activate bacterial RNA polymerase transcription.

AB - Bacteriophage T4 AsiA, a strong inhibitor of bacterial RNA polymerase, was the first antisigma protein to be discovered. Recent advances that made it possible to purify large amounts of this highly toxic protein led to an increased understanding of AsiA function and structure. In this review, we discuss how the small 10-KDa AsiA protein plays a key role in T4 development through its ability to both inhibit and activate bacterial RNA polymerase transcription.

KW - Antisigma

KW - Bacteriophase T4

KW - RNA polymerase

KW - Transcription regulation

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DO - 10.1016/j.pep.2004.09.019

M3 - Review article

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SN - 1046-5928

VL - 41

SP - 1

EP - 8

JO - Protein Expression and Purification

JF - Protein Expression and Purification

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ER -

Transcription regulation by bacteriophage T4 AsiA

Abstract

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