Transcriptional and post-transcriptional mechanisms of the development of neocortical lamination

Tatiana Popovitchenko, Mladen Roko Rasin

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


The neocortex is a laminated brain structure that is the seat of higher cognitive capacity and responses, long-term memory, sensory and emotional functions, and voluntary motor behavior. Proper lamination requires that progenitor cells give rise to a neuron, that the immature neuron can migrate away from its mother cell and past other cells, and finally that the immature neuron can take its place and adopt a mature identity characterized by connectivity and gene expression; thus lamination proceeds through three steps: genesis, migration, and maturation. Each neocortical layer contains pyramidal neurons that share specific morphological and molecular characteristics that stem from their prenatal birth date. Transcription factors are dynamic proteins because of the cohort of downstream factors that they regulate. RNA-binding proteins are no less dynamic, and play important roles in every step of mRNA processing. Indeed, recent screens have uncovered post-transcriptional mechanisms as being integral regulatory mechanisms to neocortical development. Here, we summarize major aspects of neocortical laminar development, emphasizing transcriptional and post-transcriptional mechanisms, with the aim of spurring increased understanding and study of its intricacies.

Original languageEnglish (US)
Article number102
JournalFrontiers in Neuroanatomy
StatePublished - Nov 9 2017

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Neuroscience (miscellaneous)
  • Cellular and Molecular Neuroscience


  • Alternative splicing
  • Mouse neocortex
  • Neocortical lamination
  • Neurogenesis
  • Posttranscriptional regulation
  • Pyramidal neuron
  • RNA-binding proteins
  • Transcription factors


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