Transdermal and transbuccal drug delivery systems: Enhancement using iontophoretic and chemical approaches

Longsheng Hu, Sérgio M.C. Silva, Bassam B. Damaj, Richard Martin, Bozena B. Michniak-Kohn

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

We investigated the enhancement effect of chemical enhancers and iontophoresis on the in vitro transdermal and transbuccal delivery of lidocaine HCl (LHCl), nicotine hydrogen tartrate (NHT), and diltiazem HCl (DHCl) using porcine skin and buccal tissues. Dodecyl 2-(N,N-dimethylamino) propionate (DDAIP), dodecyl-2-(N,N-dimethylamino) propionate hydrochloride (DDAIP HCl), N-(4-bromobenzoyl)-S,S-dimethyliminosulfurane (Br-iminosulfurane), and azone (laurocapram) were used as chemical enhancers. The study results showed that the application of iontophoresis at either 0.1 mA or 0.3 mA significantly enhanced transdermal and transmucosal delivery of LHCl, NHT and DHCl. It was also demonstrated that iontophoresis had a more pronounced enhancement effect on transdermal delivery than on transbuccal delivery of LHCl, NHT and DHCl. In addition, DDAIP HCl was found to be the most effective enhancer for transbuccal delivery of LHCl and NHT.

Original languageEnglish (US)
Pages (from-to)53-62
Number of pages10
JournalInternational Journal of Pharmaceutics
Volume421
Issue number1
DOIs
StatePublished - Dec 12 2011

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Chemical enhancer
  • Diltiazem hydrochloride
  • Iontophoresis
  • Lidocaine hydrochloride
  • Nicotine hydrogen tartrate
  • Transdermal and transbuccal drug delivery

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