Transforming growth factor-β: Biology and clinical relevance

Isaac Yi Kim, Moses M. Kim, Seong Jin Kim

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations


Transforming growth factor-β is a pleiotropic growth factor that has enthralled many investigators for approximately two decades. In addition to many reports that have clarified the basic mechanism of transforming growth factor-β signal transduction, numerous laboratories have published on the clinical implication/application of transforming growth factor-β. To name a few, dysregulation of transforming growth factor-β signaling plays a role in carcinogenesis, autoimmunity, angiogenesis, and wound healing. In this report, we will review these clinical implications of transforming growth factor-β.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalJournal of Biochemistry and Molecular Biology
Issue number1
StatePublished - 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology


  • Cell cycle
  • Signal
  • Smad
  • TGF-β
  • Tumor suppressor
  • Wound healing


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