Transgenerational epigenetics and brain disorders

Nadia Rachdaoui, Dipak K. Sarkar

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Scopus citations

Abstract

Neurobehavioral and psychiatric disorders are complex diseases with a strong heritable component; however, to date, genome-wide association studies failed to identify the genetic loci involved in the etiology of these brain disorders. Recently, transgenerational epigenetic inheritance has emerged as an important factor playing a pivotal role in the inheritance of brain disorders. This field of research provides evidence that environmentally induced epigenetic changes in the germline during embryonic development can be transmitted for multiple generations and may contribute to the etiology of brain disease heritability. In this review, we discuss some of the most recent findings on transgenerational epigenetic inheritance. We particularly discuss the findings on the epigenetic mechanisms involved in the heritability of alcohol-induced neurobehavioral disorders such as fetal alcohol spectrum disorders.

Original languageEnglish (US)
Title of host publicationInternational Review of Neurobiology
PublisherAcademic Press Inc.
Pages51-73
Number of pages23
DOIs
StatePublished - 2014

Publication series

NameInternational Review of Neurobiology
Volume115
ISSN (Print)0074-7742

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Keywords

  • DNA methylation
  • Germline
  • Histone
  • Inheritance
  • Neuronal disease
  • Transgenerational

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