Transient neutropenia induced by transfusion of blood exposed to nylon fiber filters

C. A. Schiffer, J. Aisner, P. H. Wiernik

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30 Scopus citations


During the course of granulocyte collection by continuous flow filtration leukopheresis, an abrupt fall in neutrophil count was noted (mean decrease 77%, range 64% to 95%). Neutrogenia occurred within 5 min of return of blood exposed to the nylon fiber filters and lasted less than 30 min. Saline exposed to the fibers, withdrawal and reinfusion of whole blood, and heparin did not cause neutropenia. Heparinized blood passed by gravity through isolated filters and reinfused immediately also induced neutropenia (mean decrease 64% ± 8%, range 11% to 19%). Blood anticoagulated with ACD (acid citrate dextrose) (decrease 19.5% ± 6%, range 6% to 56%), heparinized plasma (N = 10, decrease 15% ± 3%, range 3% to 29%) and platelet rich plasma exposed to the filters failed to produce neutropenia. 91% ± 2% of the neutrophils adhered to the fibers using heparinized blood as compared to 21% ± 5% using ACD (p < 0.001). All donors were asymptomatic during the infusions. These results suggest that during neutrophil adherence a substance is released which produces profound, transient neutropenia perhaps by inducing margination of cells.

Original languageEnglish (US)
Pages (from-to)141-146
Number of pages6
Issue number1
StatePublished - 1975
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology


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