Translational potential of systems-based models of inflammation.

P. T. Foteinou, S. E. Calvano, S. F. Lowry, I. P. Androulakis

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

A critical goal of translational research is to convert basic science to clinically relevant actions related to disease prevention, diagnosis, and eventually enable physicians to identify and evaluate treatment strategies. Integrated initiatives are identified as valuable in uncovering the mechanism underpinning the progression of human diseases. Tremendous opportunities have emerged in the context of systems biology that aims at the deconvolution of complex phenomena to their constituent elements and the quantification of the dynamic interactions between these components through the development of appropriate computational and mathematical models. In this review, we discuss the potential role systems-based translation research can have in the quest to better understand and modulate the inflammatory response.

Original languageEnglish (US)
Pages (from-to)85-89
Number of pages5
JournalClinical and translational science
Volume2
Issue number1
DOIs
StatePublished - Feb 2009

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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