Translational potential of systems-based models of inflammation.

P. T. Foteinou, S. E. Calvano, S. F. Lowry, Ioannis Androulakis

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

A critical goal of translational research is to convert basic science to clinically relevant actions related to disease prevention, diagnosis, and eventually enable physicians to identify and evaluate treatment strategies. Integrated initiatives are identified as valuable in uncovering the mechanism underpinning the progression of human diseases. Tremendous opportunities have emerged in the context of systems biology that aims at the deconvolution of complex phenomena to their constituent elements and the quantification of the dynamic interactions between these components through the development of appropriate computational and mathematical models. In this review, we discuss the potential role systems-based translation research can have in the quest to better understand and modulate the inflammatory response.

Original languageEnglish (US)
Pages (from-to)85-89
Number of pages5
JournalClinical and translational science
Volume2
Issue number1
DOIs
StatePublished - Jan 1 2009

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Translational Medical Research
Systems Biology
Disease Progression
Theoretical Models
Inflammation
Physicians
Deconvolution
Research
Mathematical models
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Foteinou, P. T. ; Calvano, S. E. ; Lowry, S. F. ; Androulakis, Ioannis. / Translational potential of systems-based models of inflammation. In: Clinical and translational science. 2009 ; Vol. 2, No. 1. pp. 85-89.
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Translational potential of systems-based models of inflammation. / Foteinou, P. T.; Calvano, S. E.; Lowry, S. F.; Androulakis, Ioannis.

In: Clinical and translational science, Vol. 2, No. 1, 01.01.2009, p. 85-89.

Research output: Contribution to journalReview article

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