Transport models for chemotactic cell populations based on individual cell behavior

Mercedes A. Rivero, Robert T. Tranquillo, Helen M. Buettner, Douglas A. Lauffenburger

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

A simple, generalized transport equation for the migration of chemotactic cell populations is derived from a probabilistic model in one spatial dimension. This general equation is then made specific for the cases of flagellar bacteria and polymorphonuclear leukocytes, based on quantitative information concerning chemosensory movement behavior of individual cells of these types. The resulting specialized equations allow a priori estimation of the polulation transport coefficients (μ, the random motility coefficient, and x, the chemotaxis coefficient) in terms of individual cell movement properties (such as speed, directional persistence time, and directional orientation bias). Thus, our model permits cell population migration to be related quantitatively to individual cell behavior. Examples of application of our models to experimental data are provided. Despite the simplifying approximations involved in our derivations, especially in the extrapolation to higher spatial dimensions, the models demonstrate a satisfactory and very useful ability to quantitatively interpret population assays for bacterial and leukocyte chemotactic migration.

Original languageEnglish (US)
Pages (from-to)2881-2897
Number of pages17
JournalChemical Engineering Science
Volume44
Issue number12
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Cell Population
Migration
Leukocytes
Cells
Cell
Motility
Transport Coefficients
Chemotaxis
Coefficient
Extrapolation
Generalized Equation
Transport Equation
Probabilistic Model
Bacteria
Persistence
Experimental Data
Model
Assays
Approximation
Demonstrate

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering

Cite this

Rivero, Mercedes A. ; Tranquillo, Robert T. ; Buettner, Helen M. ; Lauffenburger, Douglas A. / Transport models for chemotactic cell populations based on individual cell behavior. In: Chemical Engineering Science. 1989 ; Vol. 44, No. 12. pp. 2881-2897.
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Transport models for chemotactic cell populations based on individual cell behavior. / Rivero, Mercedes A.; Tranquillo, Robert T.; Buettner, Helen M.; Lauffenburger, Douglas A.

In: Chemical Engineering Science, Vol. 44, No. 12, 01.01.1989, p. 2881-2897.

Research output: Contribution to journalArticle

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