Transport of single molecules through nanochannels: A novel approach to DNA sequencing

Rattikan Chantiwas, Mateusz L. Hupert, Jesús Tamarit López, Proyag Datta, Jost Gottert, Brian Novak, Dorel Moldovan, Shantenu Jha, Sunggook Park, Michael C. Murphy, Dimitris E. Nikitopoulos, Steven A. Soper

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Understanding the transport dynamics of single molecules through 1D and 2D nano-channels is a fundamental prerequisite toward designing high-throughput systems for DNA sequencing. Our efforts are focused on the fabrication of the prerequisite structures using replication technology to produce both nano- and micro-scale channels in polymeric substrates with the size of these channels equal to or less than the persistence length of a dsDNA biopolymer. Molecular dynamics is being used to study the transport of DNA mononucleotides through 1D molecular-scale channels for identification.

Original languageEnglish (US)
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages177-179
Number of pages3
ISBN (Print)9780979806421
Publication statusPublished - Jan 1 2009
Externally publishedYes
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: Nov 1 2009Nov 5 2009

Publication series

NameProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
CountryKorea, Republic of
CityJeju
Period11/1/0911/5/09

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All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Keywords

  • DNA sequencing
  • Nanochannels
  • Single molecules

Cite this

Chantiwas, R., Hupert, M. L., López, J. T., Datta, P., Gottert, J., Novak, B., ... Soper, S. A. (2009). Transport of single molecules through nanochannels: A novel approach to DNA sequencing. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 177-179). (Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.