Treatment of acute graft-vs-host disease after simultaneous pancreas-kidney transplantation: A case report

A. J. Osband, D. A. Laskow, R. A. Mann

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Whereas neutropenia is common after solid-organ transplantation, graft-vs-host disease is unusual, especially after simultaneous pancreas-kidney transplantation. Most cases reported in the literature give few details of treatment approach, and all were fatal. A 45-year-old man with diabetes underwent simultaneous pancreas-kidney transplantation at our center, with organs from a female donor. Two weeks postoperatively, he was readmitted with fever, malaise, and neutropenia. A bone marrow biopsy specimen demonstrated that two-thirds of the lymphocytes were of female karyotype. Graft-vs-host disease was diagnosed. Aggressive immunosuppression therapy was administered; however, the patient died. To our knowledge, this is the first case report with specific details of a treatment protocol and sequential short tandem repeat data.

Original languageEnglish (US)
Pages (from-to)3894-3897
Number of pages4
JournalTransplantation Proceedings
Volume42
Issue number9
DOIs
StatePublished - Nov 2010

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

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