Treatment of chemotherapy extravasation: Current status

Because the information defining local toxicity of various chemotherapy agents is scant, information regarding effective treatment is similarly lacking or anecdotal at best. The problems of differing mechanisms of tissue damage, inadequacies in the animal models, and inability to effectively utilize the clinical situation for research have thwarted the development of effective treatments for local chemotherapy toxicity. This paper will define chemotherapy agents with local toxicity and will review the research methods and treatment modalities as currently known.