Treatment of mice with methamphetamine produces cell loss in the substantia nigra

Patricia K. Sonsalla, Nina D. Jochnowitz, Gail D. Zeevalk, Jo A. Oostveen, Edward D. Hall

Research output: Contribution to journalArticlepeer-review

131 Scopus citations

Abstract

Studies were conducted to determine if treatment of mice with methamphetamine (METH) would produce a loss of dopaminergic cells in the substantia nigra. The number of TH+/Nissl-stained cells was significantly decreased in both Swiss-Webster (S-W) and C57bl mice (approx. cell loss of 40% and 45%, respectively) 5-8 days after treatment with METH. In these same mice there was a corresponding decrease in neostriatal dopamine (DA) content (90% and 92%, respectively). In parallel studies, treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produced similar neuropathological effects. The finding that nigral cell loss occurs after METH treatment indicates that the METH-treated mouse may be a very relevant model of Parkinson's disease (PD).

Original languageEnglish (US)
Pages (from-to)172-175
Number of pages4
JournalBrain research
Volume738
Issue number1
DOIs
StatePublished - Oct 28 1996

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
  • animal model of Parkinson's disease
  • dopaminergic neurotoxicity
  • methamphetamine
  • mice
  • nigral cell loss
  • substantia nigra neuropathology

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