@article{34509156a2524fbf93425a7423f9eea6,
title = "Triarylboron-Doped Acenethiophenes as Organic Sonosensitizers for Highly Efficient Sonodynamic Therapy with Low Phototoxicity",
abstract = "The development of efficient organic sonosensitizers is crucial for sonodynamic therapy (SDT) in the field of cancer treatment. Herein, a new strategy for the development of efficient organic sonosensitizers based on triarylboron-doped acenethiophene scaffolds is presented. The attachment of boron to the linear acenethiophenes lowers the lowest unoccupied molecular orbital (LUMO) energy, resulting in redshifted absorptions and emissions. After encapsulation with the amphiphilic polymer DSPE-mPEG2000, it is found that the nanostructured BAnTh-NPs and BTeTh-NPs (nanoparticles of BAnTh and BTeTh) shows efficient hydroxyl radical (•OH) generation under ultrasound (US) irradiation in aqueous solution with almost no phototoxicity, which can overcome the shortcomings of O2-dependent SDT and avoid the potential cutaneous phototoxicity issue. In vitro and in vivo therapeutic results validate that boron-doped acenethiophenes as sonosensitizers enable high SDT efficiency with low phototoxicity and good biocompatibility, indicating that boron-functionalization of acenes is a promising strategy toward organic sonosensitizers for SDT.",
keywords = "heteroacenes, hydroxyl radicals, sonodynamic therapy, sonosensitizers, triarylboron",
author = "Kanglei Liu and Zhenqi Jiang and Fenggui Zhao and Weizhi Wang and Frieder J{\"a}kle and Nan Wang and Xiaoying Tang and Xiaodong Yin and Pangkuan Chen",
note = "Funding Information: This work was financially supported by the National Natural Science Foundation of China (52172045, 22101025, 32101153), and the Project of China Postdoctoral Science Foundation (2020M680362, 2020M680395). F.J. thanks the US National Science Foundation (Grant CHE‐1954122) for support. All of the experimental protocols involving animals were approved by the Regional Ethics Committee for Animal Experiments at the Beijing Institute of Technology (Permit No. SYXK Jing 2017‐0031). The authors acknowledge the Analysis and Testing center of Beijing Institute of Technology for characterization in NMR, MS, and Dr. Hongwei Ma for X‐ray single‐crystal diffraction. The authors acknowledge the Analysis Center, Department of Chemistry at Tsinghua University for ESR experiments. Funding Information: This work was financially supported by the National Natural Science Foundation of China (52172045, 22101025, 32101153), and the Project of China Postdoctoral Science Foundation (2020M680362, 2020M680395). F.J. thanks the US National Science Foundation (Grant CHE-1954122) for support. All of the experimental protocols involving animals were approved by the Regional Ethics Committee for Animal Experiments at the Beijing Institute of Technology (Permit No. SYXK Jing 2017-0031). The authors acknowledge the Analysis and Testing center of Beijing Institute of Technology for characterization in NMR, MS, and Dr. Hongwei Ma for X-ray single-crystal diffraction. The authors acknowledge the Analysis Center, Department of Chemistry at Tsinghua University for ESR experiments. Publisher Copyright: {\textcopyright} 2022 Wiley-VCH GmbH.",
year = "2022",
month = dec,
day = "8",
doi = "10.1002/adma.202206594",
language = "English (US)",
volume = "34",
journal = "Advanced Materials",
issn = "0935-9648",
publisher = "Wiley-VCH Verlag",
number = "49",
}