Trichinella spiralis: Site selection by the larva during the enteral phase of infection in mice

Dickson D. Despommier; Michael Sukhdeo; Eugene Meerovitch

doi:10.1016/0014-4894(78)90100-5

Trichinella spiralis: Site selection by the larva during the enteral phase of infection in mice

Dickson D. Despommier, Michael Sukhdeo, Eugene Meerovitch

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Mice, belonging to two strains, were infected by the oral route with muscle larvae of Trichinella spiralis. Host animals were killed at various times up to 48 hr after administration of larvae, and the infected small intestines were fixed immediately in 10% neutral formalin. Sections of infected gut, embedded in paraffin and cut at 5 μm, or in methacrylate and cut at 0.5 μm, revealed that all stages (i.e., 1 to 4) of T. spiralis were embedded between the lamina propria and the columnar epithelium. First-stage muscle larvae occupied this niche as early as 10 min after introducing them into the host by the oral route.

Original language	English (US)
Pages (from-to)	209-215
Number of pages	7
Journal	Experimental Parasitology
Volume	44
Issue number	2
DOIs	https://doi.org/10.1016/0014-4894(78)90100-5
State	Published - Apr 1978
Externally published	Yes

All Science Journal Classification (ASJC) codes

Parasitology
Immunology
Infectious Diseases

Keywords

Adult
Columnar epithelium
Enteral phase
Lamina propria
Mouse
Niche
Parasitic nematode
Small intestine
Trichinella spiralis

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10.1016/0014-4894(78)90100-5

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title = "Trichinella spiralis: Site selection by the larva during the enteral phase of infection in mice",

abstract = "Mice, belonging to two strains, were infected by the oral route with muscle larvae of Trichinella spiralis. Host animals were killed at various times up to 48 hr after administration of larvae, and the infected small intestines were fixed immediately in 10% neutral formalin. Sections of infected gut, embedded in paraffin and cut at 5 μm, or in methacrylate and cut at 0.5 μm, revealed that all stages (i.e., 1 to 4) of T. spiralis were embedded between the lamina propria and the columnar epithelium. First-stage muscle larvae occupied this niche as early as 10 min after introducing them into the host by the oral route.",

keywords = "Adult, Columnar epithelium, Enteral phase, Lamina propria, Mouse, Niche, Parasitic nematode, Small intestine, Trichinella spiralis",

author = "Despommier, {Dickson D.} and Michael Sukhdeo and Eugene Meerovitch",

note = "Funding Information: William Henick, Eric Grave, Lorna Aron, and John Karapelou are thanked for their assistance. The senior author is the recipient of Career Development Award No. 5K04-A170255 from the U.S. National Institutes of Health. This work was supported, in part, by Research Grant No. 3-ROl-AI 10627 from the U.S. National. Institutes of Health and by the National Research Council of Canada, as well as the Formation des Chercheurs et d{\textquoteright}Action Carcertee, Programme du Ministere de 1{\textquoteright}Education du Quebec, Canada.",

year = "1978",

month = apr,

doi = "10.1016/0014-4894(78)90100-5",

language = "English (US)",

volume = "44",

pages = "209--215",

journal = "Experimental Parasitology",

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AU - Despommier, Dickson D.

AU - Sukhdeo, Michael

AU - Meerovitch, Eugene

N1 - Funding Information: William Henick, Eric Grave, Lorna Aron, and John Karapelou are thanked for their assistance. The senior author is the recipient of Career Development Award No. 5K04-A170255 from the U.S. National Institutes of Health. This work was supported, in part, by Research Grant No. 3-ROl-AI 10627 from the U.S. National. Institutes of Health and by the National Research Council of Canada, as well as the Formation des Chercheurs et d’Action Carcertee, Programme du Ministere de 1’Education du Quebec, Canada.

PY - 1978/4

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N2 - Mice, belonging to two strains, were infected by the oral route with muscle larvae of Trichinella spiralis. Host animals were killed at various times up to 48 hr after administration of larvae, and the infected small intestines were fixed immediately in 10% neutral formalin. Sections of infected gut, embedded in paraffin and cut at 5 μm, or in methacrylate and cut at 0.5 μm, revealed that all stages (i.e., 1 to 4) of T. spiralis were embedded between the lamina propria and the columnar epithelium. First-stage muscle larvae occupied this niche as early as 10 min after introducing them into the host by the oral route.

AB - Mice, belonging to two strains, were infected by the oral route with muscle larvae of Trichinella spiralis. Host animals were killed at various times up to 48 hr after administration of larvae, and the infected small intestines were fixed immediately in 10% neutral formalin. Sections of infected gut, embedded in paraffin and cut at 5 μm, or in methacrylate and cut at 0.5 μm, revealed that all stages (i.e., 1 to 4) of T. spiralis were embedded between the lamina propria and the columnar epithelium. First-stage muscle larvae occupied this niche as early as 10 min after introducing them into the host by the oral route.

KW - Adult

KW - Columnar epithelium

KW - Enteral phase

KW - Lamina propria

KW - Mouse

KW - Niche

KW - Parasitic nematode

KW - Small intestine

KW - Trichinella spiralis

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Trichinella spiralis: Site selection by the larva during the enteral phase of infection in mice

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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