Trichinella spiralis: Site selection by the larva during the enteral phase of infection in mice

Dickson D. Despommier, Michael Sukhdeo, Eugene Meerovitch

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26 Scopus citations


Mice, belonging to two strains, were infected by the oral route with muscle larvae of Trichinella spiralis. Host animals were killed at various times up to 48 hr after administration of larvae, and the infected small intestines were fixed immediately in 10% neutral formalin. Sections of infected gut, embedded in paraffin and cut at 5 μm, or in methacrylate and cut at 0.5 μm, revealed that all stages (i.e., 1 to 4) of T. spiralis were embedded between the lamina propria and the columnar epithelium. First-stage muscle larvae occupied this niche as early as 10 min after introducing them into the host by the oral route.

Original languageEnglish (US)
Pages (from-to)209-215
Number of pages7
JournalExperimental Parasitology
Issue number2
StatePublished - Jan 1 1978
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Parasitology
  • Immunology
  • Infectious Diseases


  • Adult
  • Columnar epithelium
  • Enteral phase
  • Lamina propria
  • Mouse
  • Niche
  • Parasitic nematode
  • Small intestine
  • Trichinella spiralis

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