Triple-negative breast cancers and the human mammary epithelial cell hierarchy

Shridar Ganesan, Vassiliki Karantza, Jay Oza, Deborah Toppmeyer

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Triple-negative breast cancers (TNBCs) are a diverse set of aggressive breast cancers that lack expression of estrogen and progesterone receptors, and lack HER2 amplification. Gene expression profiling has revealed distinct subsets of TNBCs, each characterized by unique patterns of gene expression and genomic changes. Comparative analysis of gene expression profiles also suggests that the different subclasses of TNBCs may arise from specific sets of mammary progenitor cell populations. In this article, recent data regarding characterization of a human mammary stem cell hierarchy and its relationship to the pathogenesis of subsets of triple-negative breast cancers will be reviewed.

Original languageEnglish (US)
Pages (from-to)49-61
Number of pages13
JournalBreast Disease
Volume32
Issue number1-2
DOIs
StatePublished - 2010

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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