Trophic factors in the pathogenesis and therapy for retinal degenerative diseases

Anton M. Kolomeyer, Marco A. Zarbin

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations

Abstract

Trophic factors are endogenously secreted proteins that act in an autocrine and/or paracrine fashion to affect vital cellular processes such as proliferation, differentiation, and regeneration, thereby maintaining overall cell homeostasis. In the eye, the major contributors of these molecules are the retinal pigment epithelial (RPE) and Müller cells. The primary paracrine targets of these secreted proteins include the photoreceptors and choriocapillaris. Retinal degenerative diseases such as age-related macular degeneration and retinitis pigmentosa are characterized by aberrant function and/or eventual death of RPE cells, photoreceptors, choriocapillaris, and other retinal cells. We discuss results of in vitro and in vivo animal studies in which candidate trophic factors, either singly or in combination, were used in an attempt to ameliorate photoreceptor and/or retinal degeneration. We also examine current trophic factor therapies as they relate to the treatment of retinal degenerative diseases in clinical studies.

Original languageEnglish (US)
Pages (from-to)134-165
Number of pages32
JournalSurvey of ophthalmology
Volume59
Issue number2
DOIs
StatePublished - Mar 2014

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Keywords

  • Age-related macular degeneration
  • Retinal degenerative diseases
  • Retinal pigment epithelium
  • Retinitis pigmentosa
  • Trophic factors

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