TRPC5 channels participate in pressure-sensing in aortic baroreceptors

On Chai Lau, Bing Shen, Ching On Wong, Yung Wui Tjong, Chun Yin Lo, Hui Chuan Wang, Yu Huang, Wing Ho Yung, Yang Chao Chen, Man Lung Fung, John Anthony Rudd, Xiaoqiang Yao

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Blood pressure is maintained within a normal physiological range by a sophisticated regulatory mechanism. Baroreceptors serve as a frontline sensor to detect the change in blood pressure. Nerve signals are then sent to the cardiovascular control centre in the brain in order to stimulate baroreflex responses. Here, we identify TRPC5 channels as a mechanical sensor in aortic baroreceptors. In Trpc5 knockout mice, the pressure-induced action potential firings in the afferent nerve and the baroreflex-mediated heart rate reduction are attenuated. Telemetric measurements of blood pressure demonstrate that Trpc5 knockout mice display severe daily blood pressure fluctuation. Our results suggest that TRPC5 channels represent a key pressure transducer in the baroreceptors and play an important role in maintaining blood pressure stability. Because baroreceptor dysfunction contributes to a variety of cardiovascular diseases including hypertension, heart failure and myocardial infarction, our findings may have important future clinical implications.

Original languageEnglish (US)
Article number11947
JournalNature communications
Volume7
DOIs
StatePublished - Jul 14 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Fingerprint

Dive into the research topics of 'TRPC5 channels participate in pressure-sensing in aortic baroreceptors'. Together they form a unique fingerprint.

Cite this