TRPM channels and magnesium in early embryonic development

Yuko Komiya, Loren W. Runnels

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Magnesium (Mg2+) is the second most abundant cellular cation and is essential for all stages of life, from the early embryo to adult. Mg2+ deficiency causes or contributes to many human diseases, including migraine headaches, Parkinson’s disease, Alzheimer’s disease, hypotension, type 2 diabetes mellitus and cardiac arrhythmias. Although the concentration of Mg2+ in the extracellular environment can vary significantly, the total intracellular Mg2+ concentration is actively maintained within a relatively narrow range (14 - 20 mM) via tight, yet poorly understood, regulation of intracellular Mg2+ by Mg2+ transporters and Mg2+-permeant ion channels. Recent studies have continued to add to the growing number of Mg2+ transporters and ion channels involved in Mg2+ homeostasis, including TRPM6 and TRPM7, members of the transient receptor potential (TRP) ion channel family. Mutations in TRPM6, including amino acid substitutions that prevent its heterooligomerization withTRPM7, occur in the rare autosomal-recessive disease hypomagnesemia with secondary hypocalcemia (HSH). Genetic ablation of either gene in mice results in early embryonic lethality, raising the question of whether these channels’ capacity to mediate Mg2+ influx plays an important role in embryonic development. Here we review what is known of the function of Mg2+ in early development and summarize recent findings regarding the function of the TRPM6 and TRPM7 ion channels during embryogenesis.

Original languageEnglish (US)
Pages (from-to)281-288
Number of pages8
JournalInternational Journal of Developmental Biology
Volume59
Issue number7-9
DOIs
StatePublished - Jan 1 2015

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All Science Journal Classification (ASJC) codes

  • Embryology
  • Developmental Biology

Keywords

  • Embryonic development
  • Gastrulation
  • Ion channel
  • Magnesium
  • TRPM6
  • TRPM7

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