Tumor-initiating activity, mutagenicity, and metabolism of methylated anthracenes

Edmond J. Lavoie, Daniel T. Coleman, Joseph E. Rice, Nora G. Geddie, Dietrich Hoffmann

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Specific methylated derivatives of anthracene are mutagenic in S. typhimurium and have tumor-initiating activity on mouse skin. In this study, the mutagenic activities of 1-, 2-, and 9-methylanthracene, 2,9- and 9,10-dimethylanthracene, 2,9, -10-trimethylanthracene, 2,3,9,10-tetramethylanthracene, and the photo-oxide of 9,10-dimethylanthracene were determined in S. typhimurium TA98 and TA100. The relative tumor-initiating activities of these compounds were also evaluated. These bioassays indicate that increased mutagenic potency and tumor-initiating activity are associated with the presence of a methyl substituent at both the 9- and 10- position of anthracene. Metabolism studies suggest that the biological activity of specific methylated anthracenes may be related to the formation of a simple epoxide adjacent to a peri-methyl substituent.

Original languageEnglish (US)
Pages (from-to)1483-1488
Number of pages6
Issue number10
StatePublished - Oct 1985

All Science Journal Classification (ASJC) codes

  • Cancer Research


Dive into the research topics of 'Tumor-initiating activity, mutagenicity, and metabolism of methylated anthracenes'. Together they form a unique fingerprint.

Cite this