Tumorigenesis in mice carrying a truncating Brca1 mutation

Thomas Ludwig, Peter Fisher, Shridar Ganesan, Argiris Efstratiadis

Research output: Contribution to journalArticlepeer-review

102 Scopus citations

Abstract

We generated mouse mutants carrying in the Brca1 locus a modification (Brca1tr) that eliminates the C-terminal half of the protein product and obtained results indicating that, depending on genetic background, the missing BRCT and/or other domains are dispensable for survival, but essential for tumor suppression. Most of the apparently hypomorphic Brca1tr/tr mutants developed various tumors. Lymphomas were detected at all ages, whereas sarcomas and carcinomas, including breast cancer, appeared after a long latency. The mammary tumors showed striking variability in histopathological patterns suggesting stochastic engagement of tumorigenic pathways in their progression, to which the Brca1tr/tr mutation was apparently a late participant.

Original languageEnglish (US)
Pages (from-to)1188-1193
Number of pages6
JournalGenes and Development
Volume15
Issue number10
DOIs
StatePublished - May 15 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

Keywords

  • Brca1
  • Mammary tumors
  • Mouse mutant

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