Tumorigenic activity of non-alternant polynuclear aromatic hydrocarbons in newborn mice

Edmond J. Lavoie; Joanne Braley; Joseph E. Rice; Abraham Rivenson

doi:10.1016/0304-3835(87)90068-1

Tumorigenic activity of non-alternant polynuclear aromatic hydrocarbons in newborn mice

Edmond J. Lavoie, Joanne Braley, Joseph E. Rice, Abraham Rivenson

Ernest Mario School of Pharmacy, Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The tumorigenic activity of benzo[b]fluoranthene, benzo[j]fluoranthene, benzo[k]fluoranthene, and indeno-[1,2,3-cd]pyrene was evaluated in newborn CD-1 mice. The total doses of these non-alternant polycyclic aromatic hydrocarbons employed in this study ranged from 0.5 to 2.1 μmol per mouse. The results of this assay indicate that both benzo[b]fluoranthene and benzo[j]fluoranthene exhibit significant tumorigenic activity. In contrast to these results, neither benzo[k]fluoranthene nor indeno[1,2,3-cd]pyrene were tumorigenic under these assay conditions.

Original language	English (US)
Pages (from-to)	15-20
Number of pages	6
Journal	Cancer Letters
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(87)90068-1
State	Published - Jan 1987

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1016/0304-3835(87)90068-1

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title = "Tumorigenic activity of non-alternant polynuclear aromatic hydrocarbons in newborn mice",

abstract = "The tumorigenic activity of benzo[b]fluoranthene, benzo[j]fluoranthene, benzo[k]fluoranthene, and indeno-[1,2,3-cd]pyrene was evaluated in newborn CD-1 mice. The total doses of these non-alternant polycyclic aromatic hydrocarbons employed in this study ranged from 0.5 to 2.1 μmol per mouse. The results of this assay indicate that both benzo[b]fluoranthene and benzo[j]fluoranthene exhibit significant tumorigenic activity. In contrast to these results, neither benzo[k]fluoranthene nor indeno[1,2,3-cd]pyrene were tumorigenic under these assay conditions.",

author = "Lavoie, {Edmond J.} and Joanne Braley and Rice, {Joseph E.} and Abraham Rivenson",

note = "Funding Information: This study was supported by National Institute of Environmental Health Sciences Grant No. ES02030.",

year = "1987",

month = jan,

doi = "10.1016/0304-3835(87)90068-1",

language = "English (US)",

volume = "34",

pages = "15--20",

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TY - JOUR

T1 - Tumorigenic activity of non-alternant polynuclear aromatic hydrocarbons in newborn mice

AU - Lavoie, Edmond J.

AU - Braley, Joanne

AU - Rice, Joseph E.

AU - Rivenson, Abraham

N1 - Funding Information: This study was supported by National Institute of Environmental Health Sciences Grant No. ES02030.

PY - 1987/1

Y1 - 1987/1

N2 - The tumorigenic activity of benzo[b]fluoranthene, benzo[j]fluoranthene, benzo[k]fluoranthene, and indeno-[1,2,3-cd]pyrene was evaluated in newborn CD-1 mice. The total doses of these non-alternant polycyclic aromatic hydrocarbons employed in this study ranged from 0.5 to 2.1 μmol per mouse. The results of this assay indicate that both benzo[b]fluoranthene and benzo[j]fluoranthene exhibit significant tumorigenic activity. In contrast to these results, neither benzo[k]fluoranthene nor indeno[1,2,3-cd]pyrene were tumorigenic under these assay conditions.

AB - The tumorigenic activity of benzo[b]fluoranthene, benzo[j]fluoranthene, benzo[k]fluoranthene, and indeno-[1,2,3-cd]pyrene was evaluated in newborn CD-1 mice. The total doses of these non-alternant polycyclic aromatic hydrocarbons employed in this study ranged from 0.5 to 2.1 μmol per mouse. The results of this assay indicate that both benzo[b]fluoranthene and benzo[j]fluoranthene exhibit significant tumorigenic activity. In contrast to these results, neither benzo[k]fluoranthene nor indeno[1,2,3-cd]pyrene were tumorigenic under these assay conditions.

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Tumorigenic activity of non-alternant polynuclear aromatic hydrocarbons in newborn mice

Abstract

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