Type 2 immunity and wound healing: Evolutionary refinement of adaptive immunity by helminths

William C. Gause; Thomas A. Wynn; Judith E. Allen

doi:10.1038/nri3476

Type 2 immunity and wound healing: Evolutionary refinement of adaptive immunity by helminths

William C. Gause, Thomas A. Wynn, Judith E. Allen

Research output: Contribution to journal › Review article › peer-review

341 Scopus citations

Abstract

Helminth-induced type 2 immune responses, which are characterized by the T helper 2 cell-associated cytokines interleukin-4 (IL-4) and IL-13, mediate host protection through enhanced tissue repair, the control of inflammation and worm expulsion. In this Opinion article, we consider type 2 immunity in the context of helminth-mediated tissue damage. We examine the relationship between the control of helminth infection and the mechanisms of wound repair, and we provide a new understanding of the adaptive type 2 immune response and its contribution to both host tolerance and resistance.

Original language	English (US)
Pages (from-to)	607-614
Number of pages	8
Journal	Nature Reviews Immunology
Volume	13
Issue number	8
DOIs	https://doi.org/10.1038/nri3476
State	Published - Aug 2013

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1038/nri3476

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title = "Type 2 immunity and wound healing: Evolutionary refinement of adaptive immunity by helminths",

abstract = "Helminth-induced type 2 immune responses, which are characterized by the T helper 2 cell-associated cytokines interleukin-4 (IL-4) and IL-13, mediate host protection through enhanced tissue repair, the control of inflammation and worm expulsion. In this Opinion article, we consider type 2 immunity in the context of helminth-mediated tissue damage. We examine the relationship between the control of helminth infection and the mechanisms of wound repair, and we provide a new understanding of the adaptive type 2 immune response and its contribution to both host tolerance and resistance.",

author = "Gause, {William C.} and Wynn, {Thomas A.} and Allen, {Judith E.}",

note = "Funding Information: The authors wish to thank F. Finkelman at the Division of Allergy and Immunology, Cincinnati Children{\textquoteright}s Hospital Medical Center, USA, for providing excellent critical com‑ ments that strengthened this manuscript. This work was partly supported by the US National Institutes of Health (NIH) grants R01AI031678 and R01AI066188 awarded to W.C.G., and T.A.W. is supported by the Intramural Research Program from the NIH National Institute of Allergy and Infectious Diseases.",

year = "2013",

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doi = "10.1038/nri3476",

language = "English (US)",

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pages = "607--614",

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AU - Gause, William C.

AU - Wynn, Thomas A.

AU - Allen, Judith E.

N1 - Funding Information: The authors wish to thank F. Finkelman at the Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, USA, for providing excellent critical com‑ ments that strengthened this manuscript. This work was partly supported by the US National Institutes of Health (NIH) grants R01AI031678 and R01AI066188 awarded to W.C.G., and T.A.W. is supported by the Intramural Research Program from the NIH National Institute of Allergy and Infectious Diseases.

PY - 2013/8

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N2 - Helminth-induced type 2 immune responses, which are characterized by the T helper 2 cell-associated cytokines interleukin-4 (IL-4) and IL-13, mediate host protection through enhanced tissue repair, the control of inflammation and worm expulsion. In this Opinion article, we consider type 2 immunity in the context of helminth-mediated tissue damage. We examine the relationship between the control of helminth infection and the mechanisms of wound repair, and we provide a new understanding of the adaptive type 2 immune response and its contribution to both host tolerance and resistance.

AB - Helminth-induced type 2 immune responses, which are characterized by the T helper 2 cell-associated cytokines interleukin-4 (IL-4) and IL-13, mediate host protection through enhanced tissue repair, the control of inflammation and worm expulsion. In this Opinion article, we consider type 2 immunity in the context of helminth-mediated tissue damage. We examine the relationship between the control of helminth infection and the mechanisms of wound repair, and we provide a new understanding of the adaptive type 2 immune response and its contribution to both host tolerance and resistance.

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Type 2 immunity and wound healing: Evolutionary refinement of adaptive immunity by helminths

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