Type II toxin-antitoxin loci: The mazEF family

Yoshihiro Yamaguchi, Masayori Inouye

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


The mazEF locus is one of the most extensively characterized toxin-antitoxin (TA) systems. MazF is an endoribonuclease that cleaves RNA at a specific sequence. MazF is conserved in most bacterial and some archaeal species. Since the discovery of MazF in Escherichia coli, a number of MazF homologues and other mRNA interferases with different mRNA cleavage specificities have been elucidated. Here we describe their unique biochemical features, the regulatory mechanisms of the MazF activity and presumed physiological roles of MazF in the cells.

Original languageEnglish (US)
Title of host publicationProkaryotic Toxin-Antitoxins
PublisherSpringer-Verlag Berlin Heidelberg
Number of pages30
ISBN (Electronic)9783642332531
ISBN (Print)3642332528, 9783642332524
StatePublished - Nov 1 2013

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)


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