Ultrasonic Relaxation Evaluation of the Thermodynamics of Syn-Anti Glycosidic Isomerization in Adenosine

Paul R. Hemmes; Leslie Oppenheimer; Frank Jordan

doi:10.1021/ja00826a010

Ultrasonic Relaxation Evaluation of the Thermodynamics of Syn-Anti Glycosidic Isomerization in Adenosine

Paul R. Hemmes, Leslie Oppenheimer, Frank Jordan

Rutgers Newark, Chemistry

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

An ultrasonic approach is proposed which is capable of measuring all thermodynamic and kinetic quantities associated with the syn-anti conformational equilibrium in nucleosides. Application of the method to adenosine indicates that both syn and anti regions are significantly populated at room temperature. Together with high resolution nmr results the proposed method promises to lead to a precise definition of the syn-anti conformational problem in solution.

Original language	English (US)
Pages (from-to)	6023-6026
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	96
Issue number	19
DOIs	https://doi.org/10.1021/ja00826a010
State	Published - Sep 1 1974

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja00826a010

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title = "Ultrasonic Relaxation Evaluation of the Thermodynamics of Syn-Anti Glycosidic Isomerization in Adenosine",

abstract = "An ultrasonic approach is proposed which is capable of measuring all thermodynamic and kinetic quantities associated with the syn-anti conformational equilibrium in nucleosides. Application of the method to adenosine indicates that both syn and anti regions are significantly populated at room temperature. Together with high resolution nmr results the proposed method promises to lead to a precise definition of the syn-anti conformational problem in solution.",

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AB - An ultrasonic approach is proposed which is capable of measuring all thermodynamic and kinetic quantities associated with the syn-anti conformational equilibrium in nucleosides. Application of the method to adenosine indicates that both syn and anti regions are significantly populated at room temperature. Together with high resolution nmr results the proposed method promises to lead to a precise definition of the syn-anti conformational problem in solution.

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Ultrasonic Relaxation Evaluation of the Thermodynamics of Syn-Anti Glycosidic Isomerization in Adenosine

Abstract

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