Ultrasonic Relaxation Evaluation of the Thermodynamics of Syn-Anti Glycosidic Isomerization in Adenosine

Paul R. Hemmes, Leslie Oppenheimer, Frank Jordan

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

An ultrasonic approach is proposed which is capable of measuring all thermodynamic and kinetic quantities associated with the syn-anti conformational equilibrium in nucleosides. Application of the method to adenosine indicates that both syn and anti regions are significantly populated at room temperature. Together with high resolution nmr results the proposed method promises to lead to a precise definition of the syn-anti conformational problem in solution.

Original languageEnglish (US)
Pages (from-to)6023-6026
Number of pages4
JournalJournal of the American Chemical Society
Volume96
Issue number19
DOIs
StatePublished - Sep 1 1974

Fingerprint

Ultrasonic relaxation
Isomerization
Thermodynamics
Nucleosides
Ultrasonics
Adenosine
Kinetics
Temperature

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

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Ultrasonic Relaxation Evaluation of the Thermodynamics of Syn-Anti Glycosidic Isomerization in Adenosine. / Hemmes, Paul R.; Oppenheimer, Leslie; Jordan, Frank.

In: Journal of the American Chemical Society, Vol. 96, No. 19, 01.09.1974, p. 6023-6026.

Research output: Contribution to journalArticle

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