TY - JOUR
T1 - UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans
AU - Ishii, Naoaki
AU - Wadsworth, William G.
AU - Stern, Brian D.
AU - Culotti, Joseph G.
AU - Hedgecock, Edward M.
PY - 1992/11
Y1 - 1992/11
N2 - The unc-6 gene is required for the guidance of pioneer axons and migrating cells along the body wall in C. elegans. In mutants, dorsal and ventral migrations are disrupted, but longitudinal movements are largely unaffected. The gene was tagged for molecular cloning by two independent transposon insertions. Based on genomic and cDNA sequencing, the gene encodes a novel laminin-related protein, UNC-6 (591 amino acids). The N-terminus is homologous to the N-termini (i.e., domains VI, V-1, V-2, and V-3) of laminin subunits, while the C-terminus is a unique domain. We propose that UNC-6 is a component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis.
AB - The unc-6 gene is required for the guidance of pioneer axons and migrating cells along the body wall in C. elegans. In mutants, dorsal and ventral migrations are disrupted, but longitudinal movements are largely unaffected. The gene was tagged for molecular cloning by two independent transposon insertions. Based on genomic and cDNA sequencing, the gene encodes a novel laminin-related protein, UNC-6 (591 amino acids). The N-terminus is homologous to the N-termini (i.e., domains VI, V-1, V-2, and V-3) of laminin subunits, while the C-terminus is a unique domain. We propose that UNC-6 is a component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis.
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U2 - 10.1016/0896-6273(92)90240-E
DO - 10.1016/0896-6273(92)90240-E
M3 - Article
C2 - 1329863
AN - SCOPUS:0026481173
SN - 0896-6273
VL - 9
SP - 873
EP - 881
JO - Neuron
JF - Neuron
IS - 5
ER -