TY - JOUR
T1 - Undernutrition and Tuberculosis
T2 - Public Health Implications
AU - Sinha, Pranay
AU - Davis, Juliana
AU - Saag, Lauren
AU - Wanke, Christine
AU - Salgame, Padmini
AU - Mesick, Jackson
AU - Horsburgh, C. Robert
AU - Hochberg, Natasha S.
N1 - Funding Information:
Financial support. This work was supported by the US Civilian Research and Development Foundation (CRDF; award USB-31150-XX-13 to N. S. H., C. R. H., and P. S.); the National Science Foundation (cooperative agreement OISE-9531011 to N. S. H., C. R. H., and P. S.), with federal funds from the Government of India’s Department of Biotechnology, the Indian Council of Medical Research, the National Institutes of Health, the National Institute of Allergy and Infectious Diseases, and the Office of AIDS Research and distributed in part by CRDF Global; grant from the Warren Alpert Foundation and Boston University School of Medicine (N.S.H and P. S); the Clinical and Translational Sciences Institute (grant 1UL1TR001430 to N. S. H.); the Providence/Boston Center for AIDS Research (grant P30AI042853 to C. R. H.); and the Boston University/Rutgers Tuberculosis Research Unit (grant U19AI111276 to C. R. H.).
Publisher Copyright:
© 2018 The Author(s) 2018.
PY - 2019/4/16
Y1 - 2019/4/16
N2 - Almost 800 million people are chronically undernourished worldwide, of whom 98% are in low- and middle-income countries where tuberculosis is endemic. In many tuberculosis-endemic countries, undernutrition is a driver of tuberculosis incidence and associated with a high population attributable fraction of tuberculosis and poor treatment outcomes. Data suggest that undernutrition impairs innate and adaptive immune responses needed to control Mycobacterium tuberculosis infection and may affect responses to live vaccines, such as BCG. Given its impact on tuberculosis, addressing undernutrition will be a vital component of the World Health Organization End TB strategy. This narrative review describes the effect of undernutrition on the immune response, vaccine response, and tuberculosis incidence, severity, and treatment outcomes.
AB - Almost 800 million people are chronically undernourished worldwide, of whom 98% are in low- and middle-income countries where tuberculosis is endemic. In many tuberculosis-endemic countries, undernutrition is a driver of tuberculosis incidence and associated with a high population attributable fraction of tuberculosis and poor treatment outcomes. Data suggest that undernutrition impairs innate and adaptive immune responses needed to control Mycobacterium tuberculosis infection and may affect responses to live vaccines, such as BCG. Given its impact on tuberculosis, addressing undernutrition will be a vital component of the World Health Organization End TB strategy. This narrative review describes the effect of undernutrition on the immune response, vaccine response, and tuberculosis incidence, severity, and treatment outcomes.
KW - Undernutrition
KW - body mass index
KW - latent Mycobacterium tuberculosis infection
KW - nutrition disorders
KW - tuberculosis
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U2 - 10.1093/infdis/jiy675
DO - 10.1093/infdis/jiy675
M3 - Review article
C2 - 30476125
AN - SCOPUS:85059031615
SN - 0022-1899
VL - 219
SP - 1356
EP - 1363
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 9
M1 - jiy675
ER -