TY - JOUR
T1 - Understanding Opioid Actions, Pain and Analgesia
T2 - A Tribute to Dr. Gavril Pasternak
AU - Standifer, Kelly M.
AU - Inturrisi, Charles E.
AU - Foley, Kathleen M.
AU - Pan, Ying Xian
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/7
Y1 - 2021/7
N2 - This special issue is a tribute to our mentor, colleague and friend, Gavril W. Pasternak, MD, PhD. Homage to the breadth and depth of his work (~ 450 publications) over a 40 career in pharmacology and medicine cannot be captured fully in one special issue, but the 22 papers collected herein represent seven of the topics near and dear to Gav’s heart, and the colleagues, friends and mentees who held him near to theirs. The seven themes include: (1) sites and mechanisms of opioid actions in vivo; (2) development of novel analgesic agents; (3) opioid tolerance, withdrawal and addiction: mechanisms and treatment; (4) opioid receptor splice variants; (5) novel research tools and approaches; (6) receptor signaling and crosstalk in vitro; and (7) mentorship. This introduction to the issue summarizes contributions and includes formal and personal remembrances of Gav that illustrate his personality, warmth, and dedication to making a difference in patient care and people’s lives.
AB - This special issue is a tribute to our mentor, colleague and friend, Gavril W. Pasternak, MD, PhD. Homage to the breadth and depth of his work (~ 450 publications) over a 40 career in pharmacology and medicine cannot be captured fully in one special issue, but the 22 papers collected herein represent seven of the topics near and dear to Gav’s heart, and the colleagues, friends and mentees who held him near to theirs. The seven themes include: (1) sites and mechanisms of opioid actions in vivo; (2) development of novel analgesic agents; (3) opioid tolerance, withdrawal and addiction: mechanisms and treatment; (4) opioid receptor splice variants; (5) novel research tools and approaches; (6) receptor signaling and crosstalk in vitro; and (7) mentorship. This introduction to the issue summarizes contributions and includes formal and personal remembrances of Gav that illustrate his personality, warmth, and dedication to making a difference in patient care and people’s lives.
KW - Analgesia
KW - Kratom alkaloids
KW - Nociception/orphanin FQ
KW - Opioid receptors
KW - Opioid tolerance and withdrawal
KW - Splice variants
UR - http://www.scopus.com/inward/record.url?scp=85105858375&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85105858375&partnerID=8YFLogxK
U2 - 10.1007/s10571-021-01097-0
DO - 10.1007/s10571-021-01097-0
M3 - Comment/debate
C2 - 33978862
AN - SCOPUS:85105858375
SN - 0272-4340
VL - 41
SP - 827
EP - 834
JO - Cellular and Molecular Neurobiology
JF - Cellular and Molecular Neurobiology
IS - 5
ER -