Unilateral neostriatal kainate, but not 6-OHDA, lesions block dopamine agonist-induced ascorbate release in the neostriatum of freely moving rats

R. C. Pierce, D. W. Miller, D. B. Reising, G. V. Rebec

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Unilateral kainate lesions of the neostriatum and 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle were used to assess the role of neostriatal and ascending dopaminergic neurons, respectively, on dopamine-agonist induced release of neostriatal ascorbate as measured voltammetrically in freely moving rats. Electrochemically modified, carbon-fiber electrodes recorded the effects of direct (a combination of 10 mg/kg SKF-38393 and 1.0 mg/kg quinpirole) as well as indirect (2.5 mg/kg d-amphetamine or 20.0 mg/kg GBR-12909) dopamine agonists. Relative to controls, kainate, but not 6-OHDA, lesions abolished the ability of both direct and indirect dopamine agonists to induce neostriatal ascorbate release. These results suggest that unlike dopaminergic afferents, neostriatal output pathways play a critical role in the modulation of neostriatal ascorbate levels.

Original languageEnglish (US)
Pages (from-to)138-143
Number of pages6
JournalBrain research
Volume597
Issue number1
DOIs
StatePublished - Nov 27 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • 6-Hydroxydopamine
  • Amphetamine
  • Ascorbate
  • GBR-12909
  • Kainate
  • Neostriatum
  • Quinpirole
  • SKF-38393
  • Voltammetry

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