Universal genotyping in Tuberculosis Control Program, New York City, 2001-2003

Carla M. Clark; Cynthia R. Driver; Sonal S. Munsiff; Jeffrey R. Driscoll; Barry N. Kreiswirth; Benyang Zhao; Adeleh Ebrahimzadeh; Max Salfinger; Amy S. Piatek; Jalaa' Abdelwahab; Tracy Agerton; Sara Beatrice; Roseann Costarella; Rafael Fernandez; Dolores Gallagher; Karen Granville; Natalia Kurepina; Fabienne Laraque; Jiehui Li; Michelle Macaraig; Barun Mathema; Lucille Palumbo; Linda Parsons; Alex Ravikovitch; Harry Taber; Rachel Wiseman; Genet Zickas

doi:10.3201/eid1205.050446

Universal genotyping in Tuberculosis Control Program, New York City, 2001-2003

Carla M. Clark, Cynthia R. Driver, Sonal S. Munsiff, Jeffrey R. Driscoll, Barry N. Kreiswirth, Benyang Zhao, Adeleh Ebrahimzadeh, Max Salfinger, Amy S. Piatek, Jalaa' Abdelwahab, Tracy Agerton, Sara Beatrice, Roseann Costarella, Rafael Fernandez, Dolores Gallagher, Karen Granville, Natalia Kurepina, Fabienne Laraque, Jiehui Li, Michelle MacaraigBarun Mathema, Lucille Palumbo, Linda Parsons, Alex Ravikovitch, Harry Taber, Rachel Wiseman, Genet Zickas

Research output: Contribution to journal › Review article

46 Scopus citations

Abstract

In 2001, New York City implemented genotyping to its tuberculosis (TB) control activities by using IS6110 restriction fragment length polymorphism (RFLP) and spoligotyping to type isolates from culture-positive TB patients. Results are used to identify previously unknown links among genotypically clustered patients, unidentified sites of transmission, and potential false-positive cultures. From 2001 to 2003, spoligotype and IS6110-based RFLP results were obtained for 90.7% of eligible and 93.7% of submitted isolates. Fifty-nine (2.4%) of 2,437 patient isolates had false-positive culture results, and 205 genotype clusters were identified, with 2-81 cases per cluster. Cluster investigations yielded 57 additional links and 17 additional sites of transmission. Four additional TB cases were identified as a result of case finding initiated through cluster investigations. Length of unnecessary treatment decreased among patients with false-positive cultures.

Original language	English (US)
Pages (from-to)	719-724
Number of pages	6
Journal	Emerging Infectious Diseases
Volume	12
Issue number	5
DOIs	https://doi.org/10.3201/eid1205.050446
State	Published - May 2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Epidemiology
Microbiology (medical)
Infectious Diseases

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10.3201/eid1205.050446

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Clark, C. M., Driver, C. R., Munsiff, S. S., Driscoll, J. R., Kreiswirth, B. N., Zhao, B., Ebrahimzadeh, A., Salfinger, M., Piatek, A. S., Abdelwahab, J., Agerton, T., Beatrice, S., Costarella, R., Fernandez, R., Gallagher, D., Granville, K., Kurepina, N., Laraque, F., Li, J., ... Zickas, G. (2006). Universal genotyping in Tuberculosis Control Program, New York City, 2001-2003. Emerging Infectious Diseases, 12(5), 719-724. https://doi.org/10.3201/eid1205.050446

Clark, Carla M. ; Driver, Cynthia R. ; Munsiff, Sonal S. ; Driscoll, Jeffrey R. ; Kreiswirth, Barry N. ; Zhao, Benyang ; Ebrahimzadeh, Adeleh ; Salfinger, Max ; Piatek, Amy S. ; Abdelwahab, Jalaa' ; Agerton, Tracy ; Beatrice, Sara ; Costarella, Roseann ; Fernandez, Rafael ; Gallagher, Dolores ; Granville, Karen ; Kurepina, Natalia ; Laraque, Fabienne ; Li, Jiehui ; Macaraig, Michelle ; Mathema, Barun ; Palumbo, Lucille ; Parsons, Linda ; Ravikovitch, Alex ; Taber, Harry ; Wiseman, Rachel ; Zickas, Genet. / Universal genotyping in Tuberculosis Control Program, New York City, 2001-2003. In: Emerging Infectious Diseases. 2006 ; Vol. 12, No. 5. pp. 719-724.

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title = "Universal genotyping in Tuberculosis Control Program, New York City, 2001-2003",

abstract = "In 2001, New York City implemented genotyping to its tuberculosis (TB) control activities by using IS6110 restriction fragment length polymorphism (RFLP) and spoligotyping to type isolates from culture-positive TB patients. Results are used to identify previously unknown links among genotypically clustered patients, unidentified sites of transmission, and potential false-positive cultures. From 2001 to 2003, spoligotype and IS6110-based RFLP results were obtained for 90.7% of eligible and 93.7% of submitted isolates. Fifty-nine (2.4%) of 2,437 patient isolates had false-positive culture results, and 205 genotype clusters were identified, with 2-81 cases per cluster. Cluster investigations yielded 57 additional links and 17 additional sites of transmission. Four additional TB cases were identified as a result of case finding initiated through cluster investigations. Length of unnecessary treatment decreased among patients with false-positive cultures.",

author = "Clark, {Carla M.} and Driver, {Cynthia R.} and Munsiff, {Sonal S.} and Driscoll, {Jeffrey R.} and Kreiswirth, {Barry N.} and Benyang Zhao and Adeleh Ebrahimzadeh and Max Salfinger and Piatek, {Amy S.} and Jalaa' Abdelwahab and Tracy Agerton and Sara Beatrice and Roseann Costarella and Rafael Fernandez and Dolores Gallagher and Karen Granville and Natalia Kurepina and Fabienne Laraque and Jiehui Li and Michelle Macaraig and Barun Mathema and Lucille Palumbo and Linda Parsons and Alex Ravikovitch and Harry Taber and Rachel Wiseman and Genet Zickas",

year = "2006",

month = may,

doi = "10.3201/eid1205.050446",

language = "English (US)",

volume = "12",

pages = "719--724",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

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Clark, CM, Driver, CR, Munsiff, SS, Driscoll, JR, Kreiswirth, BN, Zhao, B, Ebrahimzadeh, A, Salfinger, M, Piatek, AS, Abdelwahab, J, Agerton, T, Beatrice, S, Costarella, R, Fernandez, R, Gallagher, D, Granville, K, Kurepina, N, Laraque, F, Li, J, Macaraig, M, Mathema, B, Palumbo, L, Parsons, L, Ravikovitch, A, Taber, H, Wiseman, R & Zickas, G 2006, 'Universal genotyping in Tuberculosis Control Program, New York City, 2001-2003', Emerging Infectious Diseases, vol. 12, no. 5, pp. 719-724. https://doi.org/10.3201/eid1205.050446

Universal genotyping in Tuberculosis Control Program, New York City, 2001-2003. / Clark, Carla M.; Driver, Cynthia R.; Munsiff, Sonal S.; Driscoll, Jeffrey R.; Kreiswirth, Barry N.; Zhao, Benyang; Ebrahimzadeh, Adeleh; Salfinger, Max; Piatek, Amy S.; Abdelwahab, Jalaa'; Agerton, Tracy; Beatrice, Sara; Costarella, Roseann; Fernandez, Rafael; Gallagher, Dolores; Granville, Karen; Kurepina, Natalia; Laraque, Fabienne; Li, Jiehui; Macaraig, Michelle; Mathema, Barun; Palumbo, Lucille; Parsons, Linda; Ravikovitch, Alex; Taber, Harry; Wiseman, Rachel; Zickas, Genet.

In: Emerging Infectious Diseases, Vol. 12, No. 5, 05.2006, p. 719-724.

Research output: Contribution to journal › Review article

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T1 - Universal genotyping in Tuberculosis Control Program, New York City, 2001-2003

AU - Clark, Carla M.

AU - Driver, Cynthia R.

AU - Munsiff, Sonal S.

AU - Driscoll, Jeffrey R.

AU - Kreiswirth, Barry N.

AU - Zhao, Benyang

AU - Ebrahimzadeh, Adeleh

AU - Salfinger, Max

AU - Piatek, Amy S.

AU - Abdelwahab, Jalaa'

AU - Agerton, Tracy

AU - Beatrice, Sara

AU - Costarella, Roseann

AU - Fernandez, Rafael

AU - Gallagher, Dolores

AU - Granville, Karen

AU - Kurepina, Natalia

AU - Laraque, Fabienne

AU - Li, Jiehui

AU - Macaraig, Michelle

AU - Mathema, Barun

AU - Palumbo, Lucille

AU - Parsons, Linda

AU - Ravikovitch, Alex

AU - Taber, Harry

AU - Wiseman, Rachel

AU - Zickas, Genet

PY - 2006/5

Y1 - 2006/5

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AB - In 2001, New York City implemented genotyping to its tuberculosis (TB) control activities by using IS6110 restriction fragment length polymorphism (RFLP) and spoligotyping to type isolates from culture-positive TB patients. Results are used to identify previously unknown links among genotypically clustered patients, unidentified sites of transmission, and potential false-positive cultures. From 2001 to 2003, spoligotype and IS6110-based RFLP results were obtained for 90.7% of eligible and 93.7% of submitted isolates. Fifty-nine (2.4%) of 2,437 patient isolates had false-positive culture results, and 205 genotype clusters were identified, with 2-81 cases per cluster. Cluster investigations yielded 57 additional links and 17 additional sites of transmission. Four additional TB cases were identified as a result of case finding initiated through cluster investigations. Length of unnecessary treatment decreased among patients with false-positive cultures.

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