Universal genotyping in Tuberculosis Control Program, New York City, 2001-2003

Carla M. Clark, Cynthia R. Driver, Sonal S. Munsiff, Jeffrey R. Driscoll, Barry N. Kreiswirth, Benyang Zhao, Adeleh Ebrahimzadeh, Max Salfinger, Amy S. Piatek, Jalaa' Abdelwahab, Tracy Agerton, Sara Beatrice, Roseann Costarella, Rafael Fernandez, Dolores Gallagher, Karen Granville, Natalia Kurepina, Fabienne Laraque, Jiehui Li, Michelle MacaraigBarun Mathema, Lucille Palumbo, Linda Parsons, Alex Ravikovitch, Harry Taber, Rachel Wiseman, Genet Zickas

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


In 2001, New York City implemented genotyping to its tuberculosis (TB) control activities by using IS6110 restriction fragment length polymorphism (RFLP) and spoligotyping to type isolates from culture-positive TB patients. Results are used to identify previously unknown links among genotypically clustered patients, unidentified sites of transmission, and potential false-positive cultures. From 2001 to 2003, spoligotype and IS6110-based RFLP results were obtained for 90.7% of eligible and 93.7% of submitted isolates. Fifty-nine (2.4%) of 2,437 patient isolates had false-positive culture results, and 205 genotype clusters were identified, with 2-81 cases per cluster. Cluster investigations yielded 57 additional links and 17 additional sites of transmission. Four additional TB cases were identified as a result of case finding initiated through cluster investigations. Length of unnecessary treatment decreased among patients with false-positive cultures.

Original languageEnglish (US)
Pages (from-to)719-724
Number of pages6
JournalEmerging Infectious Diseases
Issue number5
StatePublished - May 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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