Urinary Clearance of Cranberry Flavonol Glycosides in Humans

Yifei Wang, Ajay P. Singh, Heather N. Nelson, Amanda J. Kaiser, Nicolette C. Reker, Tisha L. Hooks, Ted Wilson, Nicholi Vorsa

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Cranberry is reported to have health benefits, including prevention of urinary tract infections and other chronic diseases, due to the high content of polyphenols, including flavonols and flavan-3-ols. The aim of this study was to determine the clearance of flavonol glycosides and flavan-3-ols and/or their metabolites in human urine. Ten healthy women volunteers ingested 240 mL of cranberry juice containing flavonol glycosides. Urine samples were collected at 0, 90, 225, and 360 min postingestion. While flavan-3-ols were not detected, five flavonol glycosides common in cranberry were identified. Quercetin-3-galactoside, the most abundant cranberry flavonol, exhibited the highest peak urine concentration (Cmax) of 1315 pg/mg creatinine, followed by quercetin-3-rhamnoside, quercetin-3-arabinoside, myricetin-3-arabinoside, and myricetin-3-galactoside. Quercetin-3-arabinoside showed delayed clearance, Cmax at 237 min (Tmax), relative to other flavonols (90-151 min). Both aglycone and the conjugated sugar moiety structure mediate the flavonol's bioavailability. Interindividual variation for bioavailability and clearance is also apparent. Metabolites, e.g. glucoronides, were not detected.

Original languageEnglish (US)
Pages (from-to)7931-7939
Number of pages9
JournalJournal of agricultural and food chemistry
Issue number42
StatePublished - Oct 26 2016

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)


  • MS-MS
  • cranberry juice
  • flavan-3-ols
  • flavonols
  • glycosides
  • human urine

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