Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease

Min Chen, Zhi Yun Du, Xi Zheng, Dong Li Li, Renping Zhou, Kun Zhang

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

This review summarizes and describes the use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease. For diagnosis of Alzheimer's disease, amyloid-β and highly phosphorylated tau protein are the major biomarkers. Curcumin was developed as an early diagnostic probe based on its natural fluorescence and high binding affinity to amyloid-β. Because of its multi-target effects, curcumin has protective and preventive effects on many chronic diseases such as cerebrovascular disease, hypertension, and hyperlipidemia. For prevention and treatment of Alzheimer's disease, curcumin has been shown to effectively maintain the normal structure and function of cerebral vessels, mitochondria, and synapses, reduce risk factors for a variety of chronic diseases, and decrease the risk of Alzheimer's disease. The effect of curcumin on Alzheimer's disease involves multiple signaling pathways: Anti-amyloid and metal iron chelating properties, antioxidation and anti-inflammatory activities. Indeed, there is a scientific basis for the rational application of curcumin in prevention and treatment of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)742-752
Number of pages11
JournalNeural Regeneration Research
Volume13
Issue number4
DOIs
StatePublished - Apr 1 2018

Fingerprint

Curcumin
Alzheimer Disease
Amyloid
Chronic Disease
Cerebrovascular Disorders
tau Proteins
Hyperlipidemias
Synapses
Mitochondria
Anti-Inflammatory Agents
Iron
Biomarkers
Fluorescence
Metals
Hypertension

All Science Journal Classification (ASJC) codes

  • Developmental Neuroscience

Keywords

  • Alzheimer's disease
  • Nerve regeneration
  • biological availability
  • chemical components
  • curcumin
  • early diagnosis
  • magnetic resonance imaging
  • neural regeneration
  • neurodegeneration
  • positron emission tomography
  • senile dementia

Cite this

Chen, Min ; Du, Zhi Yun ; Zheng, Xi ; Li, Dong Li ; Zhou, Renping ; Zhang, Kun. / Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease. In: Neural Regeneration Research. 2018 ; Vol. 13, No. 4. pp. 742-752.
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Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease. / Chen, Min; Du, Zhi Yun; Zheng, Xi; Li, Dong Li; Zhou, Renping; Zhang, Kun.

In: Neural Regeneration Research, Vol. 13, No. 4, 01.04.2018, p. 742-752.

Research output: Contribution to journalReview article

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