Use of single-site-functionalized PEG dendrons to prepare gene vectors that penetrate human mucus barriers

Anthony J. Kim, Nicholas J. Boylan, Jung Soo Suk, Minyoung Hwangbo, Tao Yu, Benjamin S. Schuster, Liudimila Cebotaru, Wojciech G. Lesniak, Joon Seok Oh, Pichet Adstamongkonkul, Ashley Y. Choi, Rangaramanujam M. Kannan, Justin Hanes

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Mucus-penetrating DNA nanoparticles: A novel synthetic strategy was used to achieve a dense PEG coating on the surface of cationic polymer-based DNA nanoparticles. The dense PEG coating (blue in scheme) endows the nanoparticles with a muco-inert surface, which enables their rapid mucus penetration (trajectory indicated by gray line) and provides efficient gene transfer in various cell types.

Original languageEnglish (US)
Pages (from-to)3985-3988
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number14
DOIs
StatePublished - Apr 2 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Keywords

  • DNA nanoparticles
  • cystic fibrosis
  • gene therapy
  • mucus-penetrating particles
  • nanotechnology

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  • Cite this

    Kim, A. J., Boylan, N. J., Suk, J. S., Hwangbo, M., Yu, T., Schuster, B. S., Cebotaru, L., Lesniak, W. G., Oh, J. S., Adstamongkonkul, P., Choi, A. Y., Kannan, R. M., & Hanes, J. (2013). Use of single-site-functionalized PEG dendrons to prepare gene vectors that penetrate human mucus barriers. Angewandte Chemie - International Edition, 52(14), 3985-3988. https://doi.org/10.1002/anie.201208556