Use of the herpes amplicon system as a vehicle for somatic gene transfer

Andrew I. Brooks, Marc W. Halterman, Howard J. Federoff

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

The study of herpes virus biology has produced two vector delivery strategies which exploit the highly evolved neuronal tropism and life cycle regulation exhibited by this class of viruses. Amplicon and recombinant herpes simplex virus systems show premise for use in gene transfer to the nervous system and although neither vector has been used in clinical trials to date, their application to gene delivery and perturbation of neuronal physiology have been well established. We will review the properties of the herpes amplicon system, and demonstrate its utility in neuroscience applications.

Original languageEnglish (US)
Pages (from-to)29-39
Number of pages11
JournalAdvanced Drug Delivery Reviews
Volume27
Issue number1
DOIs
StatePublished - Aug 11 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Gene transfer
  • Herpes simplex virus
  • Viral packaging

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