Using emerging genome data to identify conserved bone morphogenetic protein (Bmp) 2 gene expression mechanisms

Jun Hu, Bin Tian, David T. Fritz, Melissa B. Rogers

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Comparing genomes from diverse species has revealed surprisingly high conservation between proteins of vastly different organisms, e.g. 75% of pufferfish proteins have human counterparts. Thus subtle variation in the expression of master developmental control genes, like Bone Morphogenetic Protein (Bmp)2, is central to species differentiation. Understanding the evolution of the complex transcriptional and post-transcriptional mechanisms required to precisely regulate such genes requires novel, interdisciplinary approaches. We describe here our efforts towards defining Bmp2 gene expression determinants by combining functional assays with computational analyses of emerging genome data. Our results suggest that both primary sequence and more subtle parameters such as nucleotide composition control Bmp2 expression at the post-transcriptional level.

Original languageEnglish (US)
Title of host publicationCIKM 2006 Workshop - Proceedings of TMBIO 2006
Subtitle of host publicationACM First International Workshop on Text Mining in Bioinformatics
Pages15-20
Number of pages6
DOIs
StatePublished - 2006
EventTMBIO 2006: ACM 1st International Workshop on Text Mining in Bioinformatics, held in conjunction with the ACM 15th Conference on Information and Knowledge Management, CIKM 2006 - Arlington, VA, United States
Duration: Nov 10 2006Nov 10 2006

Publication series

NameProceedings of TMBIO 2006: ACM First International Workshop on Text Mining in Bioinformatics

Other

OtherTMBIO 2006: ACM 1st International Workshop on Text Mining in Bioinformatics, held in conjunction with the ACM 15th Conference on Information and Knowledge Management, CIKM 2006
Country/TerritoryUnited States
CityArlington, VA
Period11/10/0611/10/06

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Bioengineering
  • Computer Science(all)

Keywords

  • Bmp
  • Evolutionary genetics
  • Gene regulation
  • Genomics
  • Nucleotide content
  • RNA decay

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