Using iPSC-Based Models to Understand the Signaling and Cellular Phenotypes in Idiopathic Autism and 16p11.2 Derived Neurons

Luka Turkalj, Monal Mehta, Paul Matteson, Smrithi Prem, Madeline Williams, Robert J. Connacher, Emanuel DiCicco-Bloom, James H. Millonig

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that is remarkably heterogeneous at the clinical, neurobiological, and genetic levels. ASD can also affect language, a uniquely human capability, and is caused by abnormalities in brain development. Traditionally obtaining biologically relevant human cells to study ASD has been extremely difficult, but new technologies including iPSC-derived neurons and high-throughput omic techniques now provide new, exciting tools to uncover the cellular and signaling basis of ASD etiology.

Original languageEnglish (US)
Title of host publicationAdvances in Neurobiology
PublisherSpringer
Pages79-107
Number of pages29
DOIs
StatePublished - 2020

Publication series

NameAdvances in Neurobiology
Volume25
ISSN (Print)2190-5215
ISSN (Electronic)2190-5223

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

Keywords

  • Autism neural precursor cells
  • Autism signaling pathways
  • CNV 16p11.2 autism
  • Idiopathic autism
  • Syndromic autism
  • iPSCs model systems

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