TY - CHAP
T1 - Using iPSC-Based Models to Understand the Signaling and Cellular Phenotypes in Idiopathic Autism and 16p11.2 Derived Neurons
AU - Turkalj, Luka
AU - Mehta, Monal
AU - Matteson, Paul
AU - Prem, Smrithi
AU - Williams, Madeline
AU - Connacher, Robert J.
AU - DiCicco-Bloom, Emanuel
AU - Millonig, James H.
N1 - Funding Information:
Acknowledgements This work was supported by the New Jersey Governor’s Council for Medical Research and Treatment of Autism (CAUT13APS010; CAUT14APL031; CAUT15APL041, CAUT19APL014) and Nancy Lurie Marks Family Foundation for Dr. Millonig and Dr. DiCicco-Bloom; NJ Health Foundation (PC 63-19) for Dr. Millonig; Mindworks Charitable Lead Trust, and the Jewish Community, Foundation of Greater MetroWest, Rutgers School of Graduate Studies NJ for Dr. DiCicco-Bloom.
Funding Information:
This work was supported by the New Jersey Governor?s Council for Medical Research and Treatment of Autism (CAUT13APS010; CAUT14APL031; CAUT15APL041, CAUT19APL014) and Nancy Lurie Marks Family Foundation for Dr. Millonig and Dr. DiCicco-Bloom; NJ Health Foundation (PC 63-19) for Dr. Millonig; Mindworks Charitable Lead Trust, and the Jewish Community, Foundation of Greater MetroWest, Rutgers School of Graduate Studies NJ for Dr. DiCicco-Bloom.
Publisher Copyright:
© 2020, Springer Nature Switzerland AG.
PY - 2020
Y1 - 2020
N2 - Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that is remarkably heterogeneous at the clinical, neurobiological, and genetic levels. ASD can also affect language, a uniquely human capability, and is caused by abnormalities in brain development. Traditionally obtaining biologically relevant human cells to study ASD has been extremely difficult, but new technologies including iPSC-derived neurons and high-throughput omic techniques now provide new, exciting tools to uncover the cellular and signaling basis of ASD etiology.
AB - Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that is remarkably heterogeneous at the clinical, neurobiological, and genetic levels. ASD can also affect language, a uniquely human capability, and is caused by abnormalities in brain development. Traditionally obtaining biologically relevant human cells to study ASD has been extremely difficult, but new technologies including iPSC-derived neurons and high-throughput omic techniques now provide new, exciting tools to uncover the cellular and signaling basis of ASD etiology.
KW - Autism neural precursor cells
KW - Autism signaling pathways
KW - CNV 16p11.2 autism
KW - Idiopathic autism
KW - Syndromic autism
KW - iPSCs model systems
UR - http://www.scopus.com/inward/record.url?scp=85087014033&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85087014033&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-45493-7_4
DO - 10.1007/978-3-030-45493-7_4
M3 - Chapter
C2 - 32578145
AN - SCOPUS:85087014033
T3 - Advances in Neurobiology
SP - 79
EP - 107
BT - Advances in Neurobiology
PB - Springer
ER -