@article{f78a43dedd2a443fb2609e6cd3c7bec7,
title = "Using therapeutic drug monitoring to treat KPC-producing klebsiella pneumoniae central nervous system infection with ceftazidime/avibactam",
abstract = "This report describes the treatment of Klebsiella pneumoniae carbapenemase (KPC)-3-producing multidrug-resistant K. pneumoniae with ceftazidime/avibactam (CAZ-AVI) in a patient who developed postneurosurgical meningitis and bacteremia. Therapeutic drug monitoring of cerebrospinal fluid and blood samples demonstrated CAZ-AVI concentration levels 20-fold greater than the minimum inhibitory concentration in the first 60 minutes postinfusion, providing evidence for the utility of CAZ-AVI in treating KPC-Klebsiella pneumoniae central nervous system infections. ",
keywords = "Antimicrobial resistance, CNS infections, Ceftazidime/avibactam, KPC, Therapeutic drug monitoring",
author = "Mohamad Yasmin and Jennifer Hanrahan and Steven Marshall and Lodise, {Thomas P.} and Liang Chen and Federico Perez and Barry Kreiswirth and Bonomo, {Robert A.}",
note = "Funding Information: This project has been funded in whole or part with federal funds from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH) to R.A.B. under Award Numbers R01AI100560, R01AI063517, and R01AI072219. This study was also supported in part by funds and/or facilities provided by the Cleveland Department of Veterans Affairs, Award Number 1I01BX001974 to R.A.B. from the Biomedical Laboratory Research & Development Service of the VA Office of Research and Development, and the Geriatric Research Education and Clinical Center VISN 10. This study was in part supported by a grant from the National Institutes of Health (grant R01AI090155 to B.N.K).",
year = "2020",
month = sep,
day = "1",
doi = "10.1093/ofid/ofaa349",
language = "English (US)",
volume = "7",
journal = "Open Forum Infectious Diseases",
issn = "2328-8957",
publisher = "Oxford University Press",
number = "9",
}