Utilization of Fe 3+ -acinetoferrin analogs as an iron source by Mycobacterium tuberculosis

G. Marcela Rodriguez, Richard Gardner, Navneet Kaur, Otto Phanstiel

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Mycobacterium tuberculosis, the causative agent of human tuberculosis, synthesizes and secretes siderophores in order to compete for iron (an essential micronutrient). Successful iron acquisition allows M. tuberculosis to survive and proliferate under the iron-deficient conditions encountered in the host. To examine structural determinants important for iron siderophore transport in this pathogen, the citrate-based siderophores petrobactin, acinetoferrin and various acinetoferrin homologs were synthesized and used as iron transport probes. Mutant strains of M. tuberculosis deficient in native siderophore synthesis or transport were utilized to better understand the mechanisms involved in iron delivery via the synthetic siderophores. Acinetoferrin and its derivatives, especially those containing a cyclic imide group, were able to deliver iron or gallium into M. tuberculosis which promoted or inhibited, respectively, the growth of this pathogen.

Original languageEnglish (US)
Pages (from-to)93-103
Number of pages11
JournalBioMetals
Volume21
Issue number1
DOIs
StatePublished - Feb 2008

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Metals and Alloys

Keywords

  • Acinetoferrin
  • Exosiderophores
  • Iron
  • Mycobacterium tuberculosis
  • Mycobactin
  • Siderophores

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